A Case of Endoscopically Complete Remission of Esophageal Neuroendocrine Tumors by Concurrent Chemoradiation Therapy.
10.4166/kjg.2016.68.5.265
- Author:
Myung Hee KIM
1
;
Hyun Yong JEONG
;
Jae Kyu SEONG
;
Hee Seok MOON
;
Sun Hyung KANG
;
Duk Ki KIM
Author Information
1. Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon, Korea. mhs1357@cnuh.co.kr
- Publication Type:Case Report
- Keywords:
Neuroendocrine tumors;
Endoscopy;
Esophageal neoplasms
- MeSH:
Biopsy;
Carcinoma, Neuroendocrine;
Chromogranin A;
Cisplatin;
Cytoplasm;
Deglutition Disorders;
Drug Therapy;
Endoscopes, Gastrointestinal;
Endoscopy;
Esophageal Neoplasms;
Esophagus;
Etoposide;
Female;
Follow-Up Studies;
Humans;
Liver;
Lymph Nodes;
Middle Aged;
Neoplasm Metastasis;
Neuroendocrine Tumors*;
Prognosis;
Radiotherapy;
Synaptophysin;
Ulcer
- From:The Korean Journal of Gastroenterology
2016;68(5):265-269
- CountryRepublic of Korea
- Language:English
-
Abstract:
Neuroendocrine tumors (NETs) of the esophagus are extremely rare, aggressive and have a poor prognosis. Combined therapy using chemotherapy, radiotherapy and/or surgery appear effective. Here, we present a patient with a complaint of dysphagia who was diagnosed with this rare tumor. Upper gastrointestinal endoscope of a 46-year-old female revealed a localized ulcerative lesion in the middle esophagus. Histologic exam of biopsy specimens indicated a neuroendocrine carcinoma. The tumor cells were arranged in microtubular structures, with small and round cells containing scanty cytoplasm. They were positive for synaptophysin and chromogranin A on immunohistochemical staining. A computed tomography scan showed an esophageal tumor with enlarged superior mediastinal lymph nodes and about 1.2 cm sized liver metastasis, similar to findings in PET-CT scanning. The patient was prescribed chemotherapy consisting of etoposide and cisplatin, which led to regression of disease on follow-up imaging study. She continues under clinical observation. We seek to increase awareness of this exceedingly rare but hazardous disease by sharing our unexpected finding.
