Differences of Short-Term Systemic Responses in Obstructive Sleep Apnea Patient by Compliance of Continuous Positive Airway Pressure.
- Author:
Jong In JEONG
1
;
Su Jin KIM
;
Sang Duk HONG
;
Seung Kyu CHUNG
;
Hun Jong DHONG
;
Hyo Yeol KIM
Author Information
- Publication Type:Original Article
- Keywords: OSA; CPAP; Intermittent hypoxia; Oxidative stress; Compliance of CPAP
- MeSH: Apnea; Blood Cell Count; Chemistry; Compliance*; Continuous Positive Airway Pressure*; Hematocrit; Humans; Metabolic Diseases; Multivariate Analysis; Oxidative Stress; Peak Expiratory Flow Rate; Platelet Count; Sleep Apnea, Obstructive*; Triglycerides
- From:Journal of Rhinology 2015;22(2):75-81
- CountryRepublic of Korea
- Language:Korean
- Abstract: BACKGROUND: Obstructive sleep apnea (OSA) is characterized by repeated apnea, hypopnea, and micro-arousals during sleep. Many studies have described correlations between OSA and multiple systemic diseases, such as cardiovascular, cerebrovascular, and metabolic diseases. The aim of this study was to determine whether the compliance of continuous positive airway pressure (CPAP) affects the short-term systemic responses in OSA patients. METHODS: Twenty-four newly diagnosed OSA patients were enrolled. All subjects used CPAP for 4 weeks. The subjects were divided into two groups according to the rate of using CPAP over 4 hours per night. Complete blood cell count, coagulation results, blood chemistry, lipid profiles, and pulmonary function results were evaluated at baseline, and were followed up after 4 weeks. RESULTS: After CPAP treatment, WBC count, hemoglobin, hematocrit, albumin, AST, ALT, Cl, and peak expiratory flow rate (PEFR) were significantly changed in the higher compliance group (n=14), whereas platelet count and triglyceride levels were significantly changed in the lower compliance group (n=10). In multivariate analysis, the changes in WBC count, hemoglobin and hematocrit were statistically significant between the higher compliance and lower compliance groups (p=0.0056, 0.0016, and 0.0051). CONCLUSION: The compliance of CPAP affects the short-term systemic responses in OSA patient.
