The relationship between T869C polymorphism of transforming growth factor- 1 (TGF- 1) gene and bone mineral density in postmenopausal Korean women.
- Author:
Jung Gu KIM
1
;
Seok Hyun KIM
;
Young Min CHOI
;
Shin Yong MOON
;
Jin Yong LEE
Author Information
1. Department of Obstetrics and Gynecology, College of Medicine, Seoul National University, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Postmenopausal women;
TGF- 1;
T869C polymorphism;
BMD
- MeSH:
Absorptiometry, Photon;
Alkaline Phosphatase;
Alleles;
Bone Density*;
Electrophoresis;
Enzyme-Linked Immunosorbent Assay;
Female;
Femur;
Genotype;
Humans;
Immunoassay;
Polymerase Chain Reaction;
Spine
- From:Korean Journal of Obstetrics and Gynecology
2001;44(12):2236-2242
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: To investigate the relationship between the T869C polymorphism of transforming growth factor- 1 (TGF- 1) gene, serum TGF- 1 levels and bone mineral density (BMD) in postmenopausal Korean women. METHODS: The T869C polymorphism of TGF- 1 gene was analyzed by allele specific polymerase chain reaction (PCR) and electrophoresis in 296 postmenopausal Korean women. Serum bone alkaline phosphatase (BAP), CrossLaps (CTX), and TGF- 1 were measured by immunoassay, and enzyme linked immunosorbent assay respectively. BMD at the lumbar spine and proximal femur was determined by dual energy X-ray absorptiometry. RESULTS: The frequencies of the TT, TC, and CC genotypes of the T869C polymorphism were 3.3%, 93.7%, and 2.3%. There were no significant differences in BMD of the lumbar spine and proximal femur or serum BAP and CTX levels across the three TGF- 1 genotypes. No significant differences in the distribution of TGF- 1 genotypes and serum TGF- 1 levels among normal, osteopenic, and osteoporotic postmenopausal women were observed. There was no relationship between serum TGF- 1 levels and BMD at the lumbar spine and proximal femur. CONCLUSIONS: The T869C polymorphism of TGF- 1 gene is not associated with serum TGF- 1 levels and BMD in postmenopausal Korean women.
