Concomitant Occurrence of Cervical Myelopathy, Cerebral Infarction, and Peripheral Neuropathy in Systemic Lupus Erythematosus: A Case Report.
10.5535/arm.2014.38.2.263
- Author:
So Yeon KIM
1
;
Tae Sik YOON
;
Jee Hyun SUH
Author Information
1. Department of Rehabilitation Medicine, Ewha Womans University School of Medicine, Seoul, Korea. yoonreha@ewha.ac.kr
- Publication Type:Case Report
- Keywords:
Systemic lupus erythematosus;
Myelopathy;
Cerebral infarction
- MeSH:
Adult;
Antibodies;
Brain;
Central Nervous System;
Cerebral Infarction*;
Connective Tissue Diseases;
DNA;
Female;
Humans;
Hypertension;
Lupus Coagulation Inhibitor;
Lupus Erythematosus, Systemic*;
Magnetic Resonance Imaging;
Mortality;
Peripheral Nervous System Diseases*;
Risk Factors;
Spinal Cord Diseases*;
Spine;
Urinary Retention
- From:Annals of Rehabilitation Medicine
2014;38(2):263-268
- CountryRepublic of Korea
- Language:English
-
Abstract:
Systemic lupus erythematosus (SLE) is an autoimmune connective tissue disease characterized by multiorgan involvement with diverse clinical presentations. Central nervous system involvement in neuropsychiatric syndromes of SLE (NPSLE), such as cerebrovascular disease and myelopathy, is a major cause of morbidity and mortality in SLE patients. The concomitant occurrence of myelopathy, cerebrovascular disease, and peripheral neuropathy in a patient with SLE has not yet been reported. We report on a 41-year-old woman with SLE who showed motor and sensory impairment with urinary retention and was diagnosed with cervical myelopathy and acute cerebral infarction by spine and brain magnetic resonance imaging and peripheral neuropathy by electrodiagnostic examination. Even though pathogenesis of NPSLE is not well elucidated, we assume that increased antibodies of anti-double stranded DNA (anti-dsDNA), presence of lupus anticoagulant and hypertension are risk factors that have caused neuropsychiatric lupus in this patient.
