Significance of S100A2 and S100A4 Expression in the Progression of Prostate Adenocarcinoma.
10.4111/kju.2010.51.7.456
- Author:
Yong Wook KWON
1
;
In Ho CHANG
;
Kyung Do KIM
;
Young Sun KIM
;
Soon Chul MYUNG
;
Mi Kyung KIM
;
Tae Hyoung KIM
Author Information
1. Department of Urology, Chung-Ang University College of Medicine, Seoul, Korea. kthlmk@hanafos.com
- Publication Type:Original Article
- Keywords:
Prostatic hyperplasia;
Prostatic neoplasms;
S100A2 protein, human;
S100A4 protein, human
- MeSH:
Adenocarcinoma*;
Biopsy;
Calcium-Binding Proteins;
Humans;
Prostate*;
Prostatectomy;
Prostatic Hyperplasia;
Prostatic Neoplasms
- From:Korean Journal of Urology
2010;51(7):456-462
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: The aim of this study was to investigate the expression pattern of calcium-binding proteins S100A2 and S100A4. We also sought to determine the prognostic value of these markers for patients with prostate adenocarcinoma. MATERIALS AND METHODS: Immunohistochemical staining was performed to detect S100A2 and S100A4 expression in 26 tissue samples obtained during transurethral resection from patients with benign prostatic hyperplasia (BPH) and in 67 tissue samples obtained during prostate biopsy and radical prostatectomy from patients with prostate carcinoma. The immunoreactivity of these proteins was stratified on a scale of 0 to 3 and was correlated with the pathologic features of prostate adenocarcinoma. RESULTS: High expression of S100A2 was observed in the tissue of patients with BPH, whereas low or no expression was observed in prostate cancer (CaP) cells. The protein level of S100A4 was significantly higher in CaP than in BPH cells. The higher level of S100A4 observed in CaP tissue correlated with increasing tumor grade. CONCLUSIONS: Decreased expression of S100A2 and increased expression of S100A4 may be important in the progression of CaP. This finding could aid in identifying aggressive CaP. The simultaneous analysis of S100A2 and S100A4 expression in prostate tissues may be a useful prognostic marker for CaP.
