Immunohistochemical Array for Clear Cell Type Mucoepidermoid Carcinoma.
- Author:
Yeon Sook KIM
1
;
Sang Shin LEE
;
Ji Yong SONG
;
Eun Cheol KIM
;
Suk Keun LEE
Author Information
1. Department of Dental Hygiene, Cheongju University College of Dentistry, Cheongju, Korea.
- Publication Type:Original Article
- Keywords:
Oncogenes;
Immunohistochemistry;
Array
- MeSH:
Antibodies;
beta Catenin;
Brain Neoplasms;
Cadherins;
Carcinoembryonic Antigen;
Carcinoma, Mucoepidermoid;
Cell Death;
Cyclin-Dependent Kinase 4;
Immunohistochemistry;
Oncogene Proteins;
Oncogenes;
Proliferating Cell Nuclear Antigen;
Proteins;
Receptor, Epidermal Growth Factor;
Transducers;
Tumor Necrosis Factor-alpha;
Vimentin
- From:Korean Journal of Pathology
2010;44(3):284-294
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: The protein expression profile of clear cell type mucoepidermoid carcinoma (MEC) is not well known. METHODS: We examined a case of clear cell type MEC by immunohistochemical (IHC) array using 59 antibodies against oncoproteins, proliferation-related proteins, apoptosis-related proteins, growth factor-related proteins, angiogenesis-related proteins, and matrix proteins. RESULTS: MEC tumor cells showed 40 to 60% more expression of BCL-2 and cyclin-dependent kinase 4 than normal gingival tissue, and 20-40% more expression of BCL-2-associated agonist of cell death, deleted in malignant brain tumors 1, E-cadherin, eIF5A, hypoxia-inducible factor, vimentin, and Wnt-1. Expression of other proteins, including p53, epidermal growth factor receptor, proliferating cell nuclear antigen, survivin, carcinoembryonic antigen, beta-catenin, poly-ADP ribose-polymerase, etc. were relatively weak in MEC tumor cells. CONCLUSIONS: The IHC array for our MEC contained strong oncogenic signals involving Wnt-1/adenomatous polyposis coli, tumor necrosis factor a/signal transducer and activator of transcription 3/BCL-2, and pAKT pathways, signals that could result in the prolonged survival of clear tumor cells.
