Changes in Renal Function after Different Tandem Hematopoietic Stem-cell Transplantation Approaches in Patients with Multiple Myeloma.
10.3346/jkms.2011.26.10.1310
- Author:
Seok Hui KANG
1
;
Hyeon Seok HWANG
;
Hoon Suk PARK
;
In O SUN
;
Sun Ryoung CHOI
;
Byung Ha CHUNG
;
Bum Soon CHOI
;
Chul Woo YANG
;
Yong Soo KIM
;
Chang Ki MIN
;
Cheol Whee PARK
Author Information
1. Division of Nephrology, Department of Internal Medicine, Yeungnam University Hospital, Daegu, Korea.
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Multiple Myeloma;
Allogeneic Stem-Cell Transplantation;
Autologous Stem-Cell Transplantation;
Renal Function;
Tandem Transplantation
- MeSH:
Adult;
Combined Modality Therapy;
Female;
*Glomerular Filtration Rate;
*Hematopoietic Stem Cell Transplantation;
Humans;
Kidney/*physiology;
Male;
Middle Aged;
Multiple Myeloma/physiopathology/radiotherapy/*therapy;
Transplantation, Autologous;
Transplantation, Homologous;
Treatment Outcome
- From:Journal of Korean Medical Science
2011;26(10):1310-1315
- CountryRepublic of Korea
- Language:English
-
Abstract:
This study was done to observe the alteration of the estimated glomerular filtration rate (eGFR) in multiple myeloma patients according to type of tandem hematopoietic stem cell transplantation (HSCT). Forty-one patients were enrolled in this study. Twenty patients underwent autologous HSCT (auto-HSCT) and 21 patients underwent allogeneic HSCT (allo-HSCT). The changes in eGFR after the two tandem HSCT modalities were different between the two groups, according to the donor of stem cells (P = 0.016). In the auto-HSCT group, the eGFR, recorded 12 months after secondary HSCT, was significantly decreased compared with the eGFR recorded before stem cell mobilization (P = 0.005). Although there was no significant difference, the trend showed that the eGFR after allo-HSCT decreased from the previous HSCT until a month after secondary HSCT. In addition, after 6 months of secondary HSCT, the eGFR recovered to the level recorded prior to the HSCT (P = 0.062). This difference may be due to total body irradiation, a calcineurin inhibitor, or maintemance therapy. Changes in renal function would be monitored closely for these patients. The recovery of the eGFR would be a main focus for the patients treated with the total body irradiation or the calcineurin inhibitor, a progressive decline of the eGFR would be also crucial for the patients treated with maintenance therapy.
