Current Status，Key Methodological Issues，and Considerations for Standardization in Animal Experimental Study of Moxibustion on Herbal Cake
10.13288/j.11-2166/r.2026.22.018
- VernacularTitle:隔药饼灸动物实验研究现状、主要方法学问题及规范化思考
- Author:
Jianan WU
1
;
Xia YI
1
;
Lanlan WANG
1
;
Huan LIANG
1
;
Zenghui YUE
1
;
Jiawei SONG
1
Author Information
1. Hunan University of Chinese Medicine，Changsha，410208
- Publication Type:Review
- Keywords:
moxibustion on herbal cake;
animal models;
moxibustion parameters;
animal experiments design
- From:
Journal of Traditional Chinese Medicine
2026;67(22):2471-2476
- CountryChina
- Language:Chinese
-
Abstract:
Animal model selection and moxibustion parameter setting are important components of quality control in animal experiments of moxibustion on herbal cake. This paper summarizes the use of animal models， parameter settings， and research focuses in researches of moxibustion on herbal cake. Existing studies show disease-specific clustering in model use， coexistence of empirical inheritance and disease- or syndrome-related variation in parameter settings， and a relative lag in parameter-focused research compared with mechanistic studies. The main problems are insufficient justification for animal model selection， a lack of clear and interpretable rationale for parameter differences， inadequate quantification of actual stimulation dose， and insufficient control designs to distinguish the respective effects of medicinal substances， thermal stimulation， and acupoint stimulation. Accordingly， this review proposes standar-dization strategies including clarification of essential reporting elements， stratified determination of parameter ranges， direct comparative validation， and strengthened bidirectional validation between animal and clinical studies， with the aim of providing a reference for experimental design， comparison of findings， and clinical translation.
