Association between metabolic syndrome and colorectal adenoma among middle-aged and elderly patients with colorectal polyps
10.19485/j.cnki.issn2096-5087.2026.10.009
- Author:
GAO Hui
;
XIE Liang
;
WANG Linhong
;
YAO Chunyang
;
JIN Liu
;
HONG Weiwei
;
HU Jie
- Publication Type:Journal Article
- Keywords:
metabolic syndrome;
colorectal adenoma;
colorectal polyps;
middle-aged and elderly population
- From:
Journal of Preventive Medicine
2026;38(10):1017-1021
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the association between metabolic syndrome and colorectal adenoma among middle-aged and elderly patients with colorectal polyps, so as to provide evidence for intervention, prevention and control of colorectal adenoma.
Methods:Based on the Zhejiang Provincial Colorectal Cancer Screening Program from 2022 to 2023, middle-aged and elderly patients with colorectal polyps aged 50 to 74 years who underwent colonoscopy and pathological biopsy in Jiaxing City, Zhejiang Province were selected as the survey subjects. Data on gender, age, polyp type, polyp number, polyp diameter, and polyp location were collected through the Zhejiang Provincial Colorectal Cancer Screening Program Management Platform. The most recent metabolic syndrome-related indicators measured within one year before colonoscopy were collected through the Jiaxing City Regional Health Record Management System, and the body mass index (BMI) was calculated and metabolic syndrome was diagnosed. Multivariable logistic regression models were used to analyze the association between metabolic syndrome and colorectal adenoma among middle-aged and elderly patients with colorectal polyps, as well as the interaction of metabolic syndrome with polyp number, polyp diameter, polyp location on colorectal adenoma
Results:A total of 977 middle-aged and elderly patients with colorectal polyps were included, including 638 males (65.30%) and 339 females (34.70%). There were 678 patients aged 65 to 74 years (69.40%). There were 597 patients in the adenoma group (61.11%) and 380 patients in the non-adenoma group (38.89%). Multivariable logistic regression analysis showed that males, overweight/obesity and metabolic syndrome were associated with a 38.1% (OR=1.381, 95%CI: 1.050-1.816), 33.2% (OR=1.332, 95%CI: 1.022-1.737) and 38.2% (OR=1.382, 95%CI: 1.037-1.842) increased risk of colorectal adenoma, respectively. There was an interaction between metabolic syndrome and polyp diameter on colorectal adenoma (Pfor interaction<0.05). Among middle-aged and elderly patients with colorectal polyps whose polyp diameter was ≥1 cm, metabolic syndrome was statistically associated with colorectal adenoma (OR=2.206, 95%CI: 1.276-3.815). Among patients with polyp diameter <1 cm, the association between metabolic syndrome and colorectal adenoma was not statistically significant (OR=1.300, 95%CI: 0.913-1.852).
Conclusion:Metabolic syndrome increases the risk of colorectal adenoma in middle-aged and elderly patients with colorectal polyps, and it interacts with polyp diameter to further elevate the risk of colorectal adenoma.
- Full text:2026111308464662349中老年结直肠息肉患者代谢综合征与结直肠腺瘤的关联研究.pdf
