Research progress on N6-methyladenosine regulation of hippocampal neurogenesis in the treatment of ischemic stroke
10.11665/j.issn.1000-5048.2026033002
- VernacularTitle:N6-甲基腺苷调控海马神经发生在缺血性脑卒中治疗中的研究进展
- Author:
Wenxiang FAN
1
;
Ji LI
;
Wenqiang FAN
;
Chi XU
Author Information
1. 浙江大学医学院附属儿童医院临床试验管理办公室, 儿童少年健康与疾病国家临床医学研究中心, 杭州 310052;常州市第二人民医院(南京医科大学第三附属医院), 乳腺外科, 常州 213000;浙江中医药大学第三临床医学院, 浙江省针灸神经病学研究重点实验室, 杭州 310053
- Publication Type:Journal Article
- Keywords:
ischemic stroke;
N6-methyladenosine modification;
hippocampal dentate gyrus;
neurogenesis;
neural stem cells
- From:
Journal of China Pharmaceutical University
2026;57(5):701-710
- CountryChina
- Language:Chinese
-
Abstract:
Ischemic stroke (IS) is a major disease leading to death and disability, with currently limited clinical treatment options. Adult hippocampal neurogenesis mediated by endogenous neural stem cells (NSCs) offers a new therapeutic strategy for neurological functional recovery after IS. N6-methyladenosine (m6A), the most prevalent internal chemical modification in eukaryotic mRNA, dynamically regulates gene expression through its “writers”“erasers”, and “readers”. Studies have shown that m6A modification plays a central role in maintaining the balance between quiescence and proliferation of hippocampal NSCs, determining their differentiation fate, and promoting the maturation and integration of newborn neurons. Following IS, m6A modification levels and the expression of related molecules in the brain undergo significant changes. These alterations may influence various stages of neurogenesis by regulating RNA metabolism, thereby affecting brain damage repair and cognitive functional recovery. This review systematically summarizes the molecular mechanisms by which m6A modification regulates adult hippocampal neurogenesis, outlines the dynamic changes in m6A modification in the brain after IS, proposes the hypothesis that m6A may serve as a key molecular hub linking ischemic brain injury and adult hippocampal neurogenesis, and discusses the core limitations of current research as well as future directions.
