Correlation of apolipoprotein A5 and Alarin levels with glucolipid metabolism in obese Hui adolescents
10.16835/j.cnki.1000-9817.2026316
- VernacularTitle:回族肥胖青少年载脂蛋白A5和Alarin水平与糖脂代谢的相关性
- Author:
WANG Weihong, XU Lingling, JIN Jing, ZHANG Chunchen, XUE Tao
1
Author Information
1. Department of Clinical Nutrition, General Hospital of Ningxia Medical University, Yinchuan 750001, Ningxia Hui Autonomous Region, China
- Publication Type:Journal Article
- Keywords:
Obesity;
Apolipoproteins A;
Metabolism;
Regression analysis;
Adolescent;
Minority groups
- From:
Chinese Journal of School Health
2026;47(10):1485-1488
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the expression levels of apolipoprotein A5 (ApoA5) and Alarin in obese Hui adolescents and their correlation with glucolipid metabolism.
Methods:A total of 186 obese Hui adolescents who visited the General Hospital of Ningxia Medical University from March 2020 to September 2022 were enrolled and assigned as the obesity group, and their physical examination and questionnaire data were collected. Meanwhile, 140 Hui adolescents with normal physical examination results during the same period were selected as the control group. The Chi-square test and t-test were used to compare general characteristics and relevant laboratory indicators between the two groups. Logistic regression analysis was performed to identify associated factors. Pearson correlation analysis was used to explore the relationship between ApoA5, Alarin levels and glucolipid metabolism related indicators in obese Hui adolescents.
Results:The levels of fasting plasma glucose (FPG), fasting insulin (FINS), total cholesterol (TC), triglycerides (TG), and low density lipoprotein cholesterol (LDL-C) in the obesity group were higher than those in the control group, whereas the levels of high density lipoprotein cholesterol (HDL-C) and adiponectin were lower than those in the control group ( t =3.03, 4.66, 4.59, 5.23, 5.23, -5.02, -4.21, all P <0.05). The ApoA5 level in the obesity group was lower than that in the control group [(172.34±35.56) (240.61±40.35)ng/mL], while the Alarin level was higher than that in the control group [(0.32±0.05) (0.22±0.04)ng/mL] ( t =-5.32, 7.23, both P <0.05). Pearson correlation analysis showed that ApoA5 level was negatively correlated with FINS, TC, TG, and LDL-C ( r =-0.51, -0.52, -0.64, -0.55), and positively correlated with HDL-C and adiponectin ( r =0.51, 0.62); Alarin level was positively correlated with FINS, TC, TG, and LDL-C ( r =0.49, 0.67, 0.54 , 0.57), and negatively correlated with adiponectin ( r =-0.67) (all P <0.05). There were statistically significant differences in ApoA5 and Alarin levels among Hui adolescents with different degrees of obesity ( F =4.35, 6.34); further pairwise comparison showed that the ApoA5 level in the mild obesity group was higher than that in the moderate and severe obesity groups, and the level in the moderate obesity group was higher than that in the severe obesity group; the Alarin level in the mild obesity group was lower than that in the moderate and severe obesity groups, and the level in the moderate obesity group was lower than that in the severe obesity group, with statistically significant differences (all P <0.05).
Conclusions:ApoA5 is expressed at low levels whereas Alarin is expressed at high levels in obese Hui adolescents. Both are significantly correlated with glucose and lipid metabolism indicators, suggesting that they may serve as potential biomarkers for obesity and glucolipid metabolism abnormalities in Hui adolescents.
