Kinase molecular glues: a new strategy for inducing proximity to regulate protein-protein interactions
10.11665/j.issn.1000-5048.2026051403
- VernacularTitle:激酶分子胶：基于邻近诱导的蛋白-蛋白相互作用调控新策略
- Author:
Can ZHAO
1
;
Chaofan WANG
;
Xiaoyun LU
Author Information
1. 暨南大学药学院, 广州510632
- Publication Type:Journal Article
- Keywords:
induced proximity;
protein-protein interaction;
kinase molecular glue;
targeted protein degradation
- From:
Journal of China Pharmaceutical University
2026;57(5):563-574
- CountryChina
- Language:Chinese
-
Abstract:
The proximity-induced strategy artificially induces spatial proximity between a target protein and an effector protein, triggering post-translational modifications such as ubiquitination and phosphorylation, thereby realizing a pharmacological paradigm shift from "occupancy-driven" to "event-driven" modalities. Within this framework, kinase molecular glues have emerged as a novel class of therapeutic tools that enable the precise regulation of kinase functions by facilitating interactions between kinases and E3 ubiquitin ligases or other regulatory proteins. This review systematically summarizes recent advances in kinase molecular glues, encompassing three major directions: CRBN-based molecular glue degraders (MGDs), non-CRBN MGDs, and non-degrading molecular glues, to provide some reference for the research and development of molecular glues.
