Research progress on the application of mitochondrial DNA in solid organ transplantation

VernacularTitle:线粒体DNA在实体器官移植中的应用研究进展
Author: Runyi TAO ¹ ; Yizhao SUN ² ; Fan YANG ¹ ; Jinteng FENG ¹ ; Jingyi ZHANG ¹ ; Yuezhong DING ² ; Jiangnan XU ² ; Guangjian ZHANG ¹
Author Information

1. Department of Thoracic Surgery, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.
2. null.
Publication Type:ReviewArticle
Keywords: Mitochondrial DNA; Solid organ transplantation; Immune response; Immune activation; Biomarker; Transplant-related injury; Mitochondrial damage; Mitochondrial transplantation
From: Organ Transplantation 2026;17(6):1033-1039
CountryChina
Language:Chinese
Abstract: Mitochondrial DNA (mtDNA) acts as a bridge between tissue damage and immune activation, triggering innate and adaptive immune responses through multiple signaling pathways. This review introduces the biological characteristics of mtDNA and its release mechanism in solid organ transplantation-related injuries, discusses the immune responses it mediates, and further explores its relationship with graft damage and rejection in different types of solid organ transplantation. By deeply understanding the biological functions of mtDNA, new ideas are expected to be provided for promoting marginal organ repair, optimizing graft monitoring methods, and developing targeted intervention strategies for transplant-related immune responses.