Clinical application value of donor care units in the maintenance of donor organs
10.12464/j.issn.1674-7445.2026153
- VernacularTitle:捐献者维护单元在捐献供者器官维护方面的临床应用价值
- Author:
Wanjing GAO
1
;
Jixiang LIAO
1
;
Jianhui DONG
1
;
Rong MA
1
;
Ningzi SUN
1
;
Shuting CHEN
1
;
Xuyang LIU
1
;
Zhao GAO
1
;
Jihua WU
1
;
Zhiying LEI
1
;
Qingdong SU
1
;
Rong PENG
1
;
Ning WEN
1
;
Haibin LI
1
;
Xuyong SUN
1
Author Information
1. Institute of Transplant Medicine of the Second Affiliated Hospital of Guangxi Medical University, Guangxi Clinical Research Center for Organ Transplantation, Guangxi Key Laboratory of Research on Organ Donation and Transplantation, Nanning 530007, China.
- Publication Type:OriginalArticle
- Keywords:
Donor care unit;
Donor organ maintenance;
Organ output rate;
Organ utilization rate;
Kidney transplantation;
Organ quality;
Delayed graft function;
Donation after brain death
- From:
Organ Transplantation
2026;17(6):987-995
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the value and operational effectiveness of establishing a donor care unit (DCU). Methods A single-center retrospective cohort study design was adopted. The DCU of the Transplant Center of the Second Affiliated Hospital of Guangxi Medical University was officially put into use on August 1, 2023. As of April 30, 2024, 200 donors were divided into the DCU group (n=107) and the non-DCU group (n=93) based on the different donor maintenance sites. Baseline data of donors, organ maintenance management indicators, organ output and utilization were collected and analyzed; simultaneously, the perioperative effects and 1-year postoperative prognosis of 314 recipients undergoing kidney transplantation at the Transplant Medicine Institute of the Second Affiliated Hospital of Guangxi Medical University were tracked. Results Compared with the non-DCU group, the usage rate of vasoactive drugs in the DCU group was lower, the completeness rate of pathogen culture and the proportion of daytime organ acquisition surgeries were higher, the cold ischemia time of the liver was shorter, the professional maintenance time of donors was longer, but the total hospitalization cost of donors was higher (all P<0.05). The 24-hour urine volume of donors in the DCU group increased, the level of creatine kinase decreased, and electrolyte indicators such as procalcitonin, lactate, blood sodium and blood chloride improved (all P<0.05). The cardiac output rate of donors in the DCU group was higher than that of the non-DCU group (P<0.05). The perioperative indicators, 1-year postoperative survival rates and graft survival rates of kidney transplant recipients in both groups were similar, but the serum creatinine level of recipients in the DCU group was lower after 1 year (P<0.05). Conclusions The management and operation efficiency of the DCU are good. By monitoring and regulating the stable physiological state of donors, the quality of organs is guaranteed, thereby improving cardiac output rate and short-term function of the transplanted kidney. The total hospitalization cost of donors is higher, and its comprehensive benefits need to be studied. However, it provides preliminary evidence-based basis for the clinical application of the DCU.
