Investigation of a clustered pulmonary tuberculosis outbreak in Yueqing City
10.19485/j.cnki.issn2096-5087.2026.06.005
- Author:
WU Qingyan
;
MAO Jing
;
WU Kunyang
;
ZHENG Xuhang
;
WU Hailong
;
ZHAO Lina
- Publication Type:Journal Article
- Keywords:
pulmonary tuberculosis;
clustering epidemic;
epidemiological investigation;
spatial autocorrelation analysis;
whole-genome sequencing
- From:
Journal of Preventive Medicine
2026;38(6):559-563,567
- CountryChina
- Language:Chinese
-
Abstract:
Abstract:On January 22, 2024, Yueqing People's Hospital in Zhejiang Province reported a confirmed PTB case (index case) from an enterprise. Yueqing Center for Disease Control and Prevention conducted an on-site epidemiological investigation in accordance with the China Tuberculosis Prevention and Control Technical Guidelines and the Zhejiang Province Tuberculosis Cluster Infection Response Technical Plan (2022 Edition). Screening for latent tuberculosis infection (LTBI) and case confirmation were performed according to the Diagnosis for Pulmonary Tuberculosis. Two rounds of screening were carried out in March and April 2024, covering 341 individuals. A total of 122 LTBI cases were detected, with an overall detection rate of 35.78%; 23 PTB cases were identified, with an attack rate of 6.74%. The cases were predominantly male and registered residents of Liangshan Yi Autonomous Prefecture, Sichuan Province, both accounting for 65.22%. Cases were concentrated in workshops on the 2nd and 3rd floors of Zone C at the workplace, with the enterprise dormitory as the main residence. Secondary cases were diagnosed mainly between April and May 2024, and all had a clear history of exposure within the enterprise. Global spatial autocorrelation analysis showed spatial clustering of case distribution, with local hotspots identified as the inspection area on the 2nd floor and Line 1 on the 3rd floor of Zone C. There were 11 confirmed PTB cases and 12 clinically diagnosed cases. Four strains were isolated, and whole-genome sequencing analysis revealed that they belonged to Lineage 2 and Lineage 4, with pairwise single nucleotide polymorphism differences all exceeding 12. Based on the epidemiological investigation and laboratory testing, the PTB outbreak in the enterprise was determined to be a cluster outbreak resulting from multi-source importation and close contact transmission of Mycobacterium tuberculosis within the same workshop, dormitory, and household registration group, possibly associated with a concentration of migrant workers, poor ventilation in the workplace, and the lack of pre-employment PTB screening.
- Full text:2026111016291042317乐清市一起肺结核聚集性疫情调查.pdf
