Correlations between Cuproptosis and Neurodegenerative Diseases and Interventions with Traditional Chinese Medicine： A Review
10.13422/j.cnki.syfjx.20260405
- VernacularTitle:铜死亡与神经退行性疾病的相关性及中医药干预研究进展
- Author:
Huimin ZHU
1
;
Yixuan WANG
1
;
Zitong ZHAO
2
;
Zhijin WANG
2
;
Cong GAI
1
Author Information
1. School of Traditional Chinese Medicine， Beijing University of Chinese Medicine， Beijing 100029， China
2. School of Acupuncture-Moxibustion and Tuina， Beijing University of Chinese medicine， Beijing 100029， China
- Publication Type:Journal Article
- Keywords:
cuproptosis;
neurodegenerative diseases;
mitochondria;
Alzheimer's disease;
Parkinson's disease
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2026;32(23):312-321
- CountryChina
- Language:Chinese
-
Abstract:
Cuproptosis is a newly identified form of cell death triggered by copper ion dyshomeostasis， particularly characterized by the accumulation of copper in metabolic enzymes within the mitochondria. In recent years， this mechanism has garnered significant attention in the research on neurodegenerative diseases. As investigations into the pathogeneses of neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease have advanced， the role of cuproptosis in these diseases has gradually been elucidated， establishing it as a breakthrough point for understanding disease progression. The current research primarily focuses on the associations between cuproptosis-related genes and neuronal damage， aiming to unravel the regulatory networks involved in the onset and development of these diseases. However， numerous questions remain regarding the specific regulatory mechanisms of cuproptosis and its relationship with the pathological changes in neurodegenerative diseases. Against this backdrop， this article systematically reviews the research progress in the molecular regulatory networks governing cuproptosis and roles of cuproptosis in various neurodegenerative diseases， with a particular emphasis on the intrinsic link between copper dyshomeostasis， neuroinflammation， and mitochondrial metabolism. Furthermore， integrating theories of traditional Chinese medicine （TCM） with advancements in modern pharmacological research， this article explores the potential value of TCM in regulating copper metabolism and intervening in cuproptosis signaling pathways. This review aims to offer new perspectives for understanding the pathogeneses of neurodegenerative diseases and lay a theoretical foundation for developing novel prevention and treatment strategies based on the modulation of cuproptosis with TCM.
