Role of Pyroptosis in Diabetic Nephropathy and Research Progress of Traditional Chinese Medicine Intervention
10.13422/j.cnki.syfjx.20252337
- VernacularTitle:细胞焦亡在糖尿病肾病中的作用及中药干预基础研究进展
- Author:
Yanxu CHEN
1
;
Xin LIU
1
;
Li MA
2
;
Jing XU
1
;
Xianmin WANG
2
;
Hui LI
2
;
Lijuan XU
2
;
Chong WANG
2
;
Zhisheng JIN
3
Author Information
1. Xinjiang Medical University School of Traditional Chinese Medicine（TCM）， Urumqi 830000，China
2. Affiliated Hospital of TCM， Xinjiang Medical University， Urumqi 830000，China
3. Gansu University of Chinese Medicine， Lanzhou 730000，China
- Publication Type:Journal Article
- Keywords:
diabetic nephropathy;
pyroptosis;
signal pathway;
traditional Chinese medicine;
mechanism
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2026;32(23):302-311
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic nephropathy belongs to diabetic microvascular aseptic inflammation， which is the main cause of end-stage renal disease and can cause damage to the structure of glomeruli and tubulointerstitium. Pyroptosis is a potent pro-inflammatory model of programmed cell death mediated by gasdermin （GSDM） protein family， which is characterized by nuclear shrinkage， chromatin DNA fragmentation， plasma membrane rupture， cell swelling and deformation. Related studies have found that pyroptosis is closely related to the occurrence and development of diabetic nephropathy. Inhibition of pyroptosis to a certain extent can reduce diabetic renal injury， so the pathway of pyroptosis involved in the pathogenesis of diabetic nephropathy is the current research focus. The characteristics of multi-components， multi-targets and multi-pathways of traditional Chinese medicine have significant advantages in the treatment of diabetic nephropathy. Some components of traditional Chinese medicine， single traditional Chinese medicine and compound prescription of traditional Chinese medicine can improve diabetic renal injury by inhibiting pyroptosis pathway and related targets. Based on the molecular mechanism of pyroptosis， this paper clarifies the mechanism of pyroptosis in diabetic nephropathy by expounding the relationship between pyroptosis and its pathway targets and diabetic nephropathy. This paper summarizes the research status of traditional Chinese medicine in the treatment of diabetic nephropathy by interfering with related pyroptosis pathways in recent years， so as to provide perspectives and ideas for the prevention， early diagnosis， drug development and molecular treatment of diabetic nephropathy in the future.
