Traditional Chinese Medicine Treats Diabetic Nephropathy by Regulating PPARγ Signaling Pathway： A Review
10.13422/j.cnki.syfjx.20261698
- VernacularTitle:中医药调控PPARγ信号通路治疗糖尿病肾病的研究进展
- Author:
Yue WU
1
;
Jialin ZHONG
1
;
Xiaoshuo HE
1
;
Lin JIN
1
;
Yunjiao YANG
2
;
Qiu CHEN
2
Author Information
1. Chengdu University of Traditional Chinese Medicine（TCM），Chengdu 610075，China
2. Hospital of Chengdu University of TCM，Chengdu 610072，China
- Publication Type:Journal Article
- Keywords:
diabetic nephropathy;
PPARγ signaling pathway;
traditional Chinese medicine （TCM）;
TCM active constituents;
TCM formulas
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2026;32(23):292-301
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic nephropathy （DN） is one of the most common and serious microvascular complications of diabetes mellitus and represents a major cause of chronic kidney disease progression and end-stage kidney disease， thereby constituting a major public health problem that adversely affects the prognosis and quality of life of patients with diabetes mellitus. The pathogenesis and progression of DN are complex and involve multiple pathological processes， including insulin resistance， inflammation， oxidative stress， lipid deposition， podocyte injury， and renal fibrosis. Although current clinical therapies can delay the progression of DN to some extent， their effectiveness remains limited by marked interindividual variability in therapeutic response and the difficulty of fully reversing renal injury. Therefore， further elucidation of the key molecular mechanisms underlying DN and the exploration of effective therapeutic strategies are of considerable importance. In recent years， with advances in the understanding of DN pathogenesis， peroxisome proliferator-activated receptor γ （PPARγ）， an important nuclear receptor transcription factor involved in the regulation of insulin resistance， inflammation， oxidative stress， and fibrotic processes， has attracted increasing attention for its role in the development and progression of DN. Traditional Chinese medicine （TCM）， characterized by multi-component， multi-target， and multi-pathway synergistic regulation， may ameliorate pathological processes including metabolic abnormalities， inflammation， oxidative stress， lipid deposition， and renal fibrosis in DN by targeting PPARγ and its associated signaling networks. This review systematically summarizes the mechanisms by which PPARγ and its related signaling pathways regulate DN and reviews recent advances in TCM interventions targeting the PPARγ signaling pathway in DN. Such TCM interventions encompass single herbs such as Coptidis Rhizoma， active constituents such as quercetin， astragaloside Ⅳ， and trigonelline， extracts of herbs such as Plantaginis Herba and Dendrobii Nobilis Caulis， and formulas such as Huangkui capsules， Shenshuaining granules， and Mudan granules. This review aims to provide a theoretical basis for the prevention and treatment of DN with TCM.
