Mechanism of Traditional Chinese Medicine in Preventing and Treating Heart Failure Based on Macrophage Metabolism-Immune Regulatory Axis： A Review
10.13422/j.cnki.syfjx.20260564
- VernacularTitle:基于巨噬细胞代谢-免疫调控轴探讨中医药防治心力衰竭的作用机制研究进展
- Author:
Junlin ZHOU
1
;
Xiaojiao ZHANG
1
;
Jiahui CHEN
1
;
Liyu LIN
1
;
Shiyin ZHANG
1
;
Yiyi CHEN
1
;
Xiaoming DONG
1
;
Wenjie LONG
1
;
Huili LIAO
1
;
Lu LU
1
;
Zhongqi YANG
1
;
Shihao NI
1
Author Information
1. State Key Laboratory of Traditional Chinese Medicine Syndrome， The First Affiliated Hospital of Guangzhou University of Chinese Medicine， Guangzhou 510407， China
- Publication Type:Journal Article
- Keywords:
heart failure;
macrophages;
metabolic reprogramming;
metabolism-immune regulatory axis;
traditional Chinese medicine;
signaling pathway
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2026;32(23):269-282
- CountryChina
- Language:Chinese
-
Abstract:
Heart failure （HF） is the end-stage of various cardiovascular diseases， with high morbidity and mortality. The existing “new quadruple” standard treatment can hardly reverse the core pathological process of myocardial remodeling， and long-term medication may pose risks of drug resistance and adverse reactions. Therefore， new therapeutic targets and strategies are urgently needed. Metabolic reprogramming is the upstream core mechanism regulating phenotypic polarization and functional activation of macrophages， which drives the occurrence and development of HF through the core axis of metabolic reprogramming-immune imbalance-ventricular remodeling and has become a cutting-edge potential target for the prevention and treatment of HF. Traditional Chinese medicine （TCM） has a long history in the prevention and treatment of HF. A large number of studies in recent years have confirmed that different therapeutic methods of TCM can correct the polarization imbalance， restore the homeostasis of myocardial immune microenvironment， inhibit myocardial injury， and delay the pathological process of HF by targeting and regulating the metabolic reprogramming of glucose， lipids， mitochondria， and amino acids in macrophages. This paper systematically expounds the core pathological mechanism of metabolic reprogramming of macrophages in HF， sorts out the research progress of TCM in preventing and treating HF by intervening this target， analyzes the regulatory rules， summarizes the limitations of existing research， and puts forward future directions. This review aims to provide a systematic theoretical reference and new research ideas for TCM clinical diagnosis and treatment and new drug development of HF.
