Exploring Clinical Application of Phlegm-resolving and Detoxifying Prescriptions Based on Lung Cancer Treatment
10.13422/j.cnki.syfjx.20252221
- VernacularTitle:基于肺癌治疗探讨化痰解毒方药的临床应用
- Author:
Chen LI
1
;
Xiaoman WEI
2
;
Qiuying YAN
3
;
Liu LI
2
;
Liping ZHOU
1
;
Mianhua WU
2
;
Haibo CHENG
2
;
Dongdong SUN
1
Author Information
1. School of Chinese Medicine， Nanjing University of Chinese Medicine， Nanjing 210023， China
2. The First School of Clinical Medicine， Nanjing University of Chinese Medicine， Nanjing 210023， China
3. Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine for Tumor Prevention and Treatment， Nanjing 210023， China
- Publication Type:Journal Article
- Keywords:
lung cancer;
phlegm toxin;
phlegm-resolving and detoxifying Chinese herbal medicine;
efficacy mechanism;
theory of cancer-toxin pathogenesis
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2026;32(23):228-238
- CountryChina
- Language:Chinese
-
Abstract:
Lung cancer is the leading cause of cancer-related deaths worldwide. While modern medical therapies such as surgery， chemotherapy， and radiotherapy have achieved progress， they often come with severe side effects and drug resistance. Traditional Chinese medicine （TCM）， characterized by its multi-component， multi-target， and holistic regulatory properties， plays a significant role in the adjunctive treatment of lung cancer. It offers unique advantages in alleviating clinical symptoms， enhancing patients' quality of life， prolonging survival， and enhancing efficacy while reducing toxicity， serving as an important therapeutic modality for lung cancer. The theory of cancer-toxin pathogenesis proposes that phlegm-toxin is a key pathogenic factor in lung cancer， with phlegm-toxin mutual entanglement being the core pathogenesis of lung cancer. The pathogenic characteristics-viscosity， dispersion， and damage to the healthy Qi-of phlegm-toxin are closely related to the accumulation of acidic metabolic products， tumor invasion and metastasis， and immune suppression during the course of lung cancer. Phlegm resolving and toxin clearing are the core therapeutic methods for lung cancer. Such prescriptions possess dual functions of resolving phlegm and dissipating mass， as well as inhibiting tumor and detoxifying. They exert antitumor effects through multiple pathways， including regulating metabolic reprogramming of glucose and lipids， improving the acidic microenvironment of tumors， and inhibiting inflammatory signaling pathways. This paper systematically reviews the current clinical application status and mechanisms of phlegm-resolving and detoxifying Chinese herbal medicines. By integrating the theory of cancer-toxin pathogenesis with modern pharmacological research findings， this paper explores their application in lung cancer treatment and establishes a clinical application system for phlegm-resolving and detoxifying therapies in lung cancer based on phlegm-toxin pathogenesis. This system integrates ancient and modern experiences with contemporary mechanisms， aiming to provide theoretical foundations and practical references for integrated traditional and Western medicine diagnosis， treatment， and drug development for lung cancer and other conditions.
