Review on Research of Immune Subtyping Systems of Sepsis and The Correlation with Traditional Chinese Medicine Syndromes
10.13288/j.11-2166/r.2026.21.018
- VernacularTitle:脓毒症免疫分型体系及中医证候相关性研究概述
- Author:
Feng ZHOU
1
;
Shasha HE
1
;
Xiaolong XU
1
;
Yuanyuan LYU
1
;
Zhenshan ZHANG
1
;
Qingquan LIU
1
Author Information
1. Beijing Hospital of Traditional Chinese Medicine，Capital Medical University，Beijing，100010
- Publication Type:Review
- Keywords:
sepsis;
immune subtyping;
transcriptomics;
traditional Chinese medicine syndrome;
precision therapy
- From:
Journal of Traditional Chinese Medicine
2026;67(21):2359-2364
- CountryChina
- Language:Chinese
-
Abstract:
Sepsis exhibits substantial biological heterogeneity. Transcriptome-based subtyping systems， such as sepsis response signature （SRS） subtypes， molecular diagnosis and risk stratification of sepsis （MARS）， inflammation/adaptive/coagulation subtyping， and consensus transcriptomic subtypes， have provided a crucial basis for elucidating the molecular mechanisms of sepsis and guiding precision treatment. Using a literature review approach， this study systematically summarizes the immune subtyping systems of sepsis and their molecular basis， and explores the potential correspondence between traditional Chinese medicine （TCM） syndromes and immune subtypes. It is found that the heat-toxin syndrome tends to correspond to the hyperinflammatory subtype， the stasis-toxin syndrome to the coagulopathy subtype， and the deficiency syndrome to the immunosuppressive subtype. These findings may provide new insights for precision therapy of sepsis through integrated Chinese and western medicine.
