Core Pathogenesis and Prevention and Treatment Strategies for Postoperative Recurrence of Triple-Negative Breast Cancer Based on the Spatiotemporal Evolution of Cancer Collaterals
10.13288/j.11-2166/r.2026.21.007
- VernacularTitle:从癌络时空演变规律探讨三阴性乳腺癌术后复发的核心病机及防治策略
- Author:
Guanghui ZHANG
1
;
Shaohua WANG
1
;
Jinrong WANG
2
;
Conghuang LI
3
;
Shulin HE
3
;
Baojin HUA
3
;
Qiujun GUO
3
Author Information
1. Integrated Traditional Chinese and Western Medicine Hospital Affiliated to Beijing University of Chinese Medicine，Beijing 100039
2. Sujiatuo Town Community Health Service Center
3. Guang'anmen Hospital，China Academy of Chinese Medical Sciences
- Publication Type:Journal Article
- Keywords:
triple-negative breast cancer;
cancer collaterals theory;
postoperative recurrence;
toxin-stasis accumulation in collaterals;
yin deficiency with toxin hyperactivity;
regulating qi and resolving collaterals
- From:
Journal of Traditional Chinese Medicine
2026;67(21):2292-2296
- CountryChina
- Language:Chinese
-
Abstract:
Based on cancer collateral theory， this paper proposes toxin-stasis accumulation in collaterals and yin deficiency with toxin hyperactivity as the core pathogenesis of postoperative recurrence of triple-negative breast cancer. Impaired qi transformation in collateral and depletion of yin interact， contributing to toxin-stasis binding， inadequate collateral nourishment， and unrestrained yang activity. The temporal dimension emphasizes yin deficiency with toxin hyperactivity and early reactivation of latent toxin； the spatial dimension emphasizes toxin-stasis accumulation and dissemination through collaterals. Treatment follows the principle of regulating qi and resolving collaterals. Before recurrence， emphasis is placed on nourishing collaterals to restrain latent toxin； after recurrence， on resolving binding while protecting collaterals. Herbal combinations are further tailored to disorders of qi， blood， and fluid collaterals and to the sites of dissemination， integrating treatment according to recurrence status and affected collateral systems. These theoretical propositions are intended to inform clinical reasoning and require clinical validation.
