Differentiation and Treatment of Systemic Sclerosis-Associated Interstitial Lung Disease Based on the Theory of "Combined Bi （痹） Syndrome of the Body and Zang （脏） Organs"
10.13288/j.11-2166/r.2026.21.006
- VernacularTitle:基于“体脏合痹”理论辨治系统性硬化症合并间质性肺病
- Author:
Xieli MA
1
;
Quan JIANG
1
;
Xun GONG
1
;
Congmin XIA
1
;
Chuanhui YAO
1
;
Tian CHANG
1
;
Zixia LIU
1
;
Yuchen YANG
1
;
Zhengyao SHEN
1
Author Information
1. Guang'anmen Hospital，China Academy of Chinese Medical Sciences，Beijing，100053
- Publication Type:Journal Article
- Keywords:
systemic sclerosis;
interstitial lung disease;
combined bi （痹） syndrome of the body and zang （脏） organs;
simultaneous treatment of the body and zang organs
- From:
Journal of Traditional Chinese Medicine
2026;67(21):2286-2291
- CountryChina
- Language:Chinese
-
Abstract:
Based on the theory of "combined bi （痹） syndrome of the body and zang （脏）organs"， this paper elucidates the pathogenic transmission and treatment principles of systemic sclerosis-associated interstitial lung disease （SSc-ILD）. For the pattern in which the disease transmits from the body to the zang organs， the underlying pathogenesis is blood deficiency and liver constraint with cold congealing in the collaterals. The treatment principle is to nourish the blood and warm the channels， diffuse the lung and defend against pathogenic factors， so as to interrupt the inward transmission of the disease. For the pattern in which the disease transmits from the zang organs to the body， the pathogenesis may involve lung deficiency with insecurity of the exterior， liver fire attacking the lung and scorching the collaterals， or latent pathogens of phlegm and blood stasis permeating outward. The treatment principle is to tonify the lung and secure the exterior， clear the liver and purge the lung， and resolve blood stasis and unblock the collaterals， so that when the zang organs are restored， the body can be nourished. For the pattern in which the body and zang organs are simultaneously affected， the pathogenesis lies in violent toxin pathogens spreading throughout the three jiao （焦） and damaging both the body and zang organs. The treatment principle is to cool the blood and resolve toxins， resolve blood stasis and unblock the collaterals， thereby eliminating pathogenic factors from both the interior and exterior. Emphasis is placed on simultaneous treatment of the body and zang organs and dynamic syndrome differentiation and treatment， providing a new approach to understanding the pathogenesis of SSc-ILD in traditional Chinese medicine and to its stratified treatment.
