Association between AI-based whole-brain volume measurements and radiology report–based atrophy grades (A Quantitative MRI Study in Adults with and Without Type 2 Diabetes)
- VernacularTitle:Хиймэл оюунд суурилсан тархины нийт эзлэхүүний хэмжилт ба радиологичийн тайланд бүртгэгдсэн атрофийн зэрэглэлийн хамаарлыг судалсан нь (ЧШХШ2-той болон хяналтын бүлгийн тоон СРТ судалгаа)
- Author:
Tserensugir A
1
;
2
;
Oyuntugs B
3
;
Gonshigsuren D
4
;
Tuvshinjargal D
1
;
Tovuudorj A
5
;
Mungunbagana G
6
;
Munkhbaatar D
1
;
Delgerdalai Kh
1
Author Information
1. Department of Radiology, School of Medicine, MNUMS
2. Graduate School, MNUMS
3. Department of Endocrinology, School of Medicine, MNUMS
4. Department of Radiology, Grandmed Hospital
5. Department of Neurology, School of Medicine, MNUMS
6. Department of Radiology, Brilliant Hospital
- Publication Type:Journal Article
- Keywords:
brain atrophy;
automated segmentation;
brain volume;
morphometry;
neuroimaging
- From:
Mongolian Journal of Health Sciences
2026;97(7):185-189
- CountryMongolia
- Language:Mongolian
-
Abstract:
Background:The Global Cortical Atrophy (GCA) scale is widely used for visual assessment of cortical atrophy on MRI but is subject to interobserver variability. Automated brain volumetry provides objective measurements; however, its association with visual atrophy grading remains understudied in Mongolia.
Aim:To assess the association and agreement between radiology report–based atrophy grades and AI-derived whole-brain volume, and to compare brain volumes in adults with and without type 2 diabetes mellitus (T2DM).
Materials and Methods:This retrospective, single-center study included 367 adults aged ≥40 years (T2DM, n=144; controls, n=223). Intracranial volume–adjusted whole-brain volumes were obtained from 3D T1-weighted MRI using Neurophet AQUA v3.1. Atrophy severity recorded in routine radiology reports was coded from 0 to 3. Welch’s ANOVA assessed differences across grades, and ROC analysis evaluated discrimination between adjacent grades. Classification agreement was assessed using stratified five-fold cross-validation and Cohen’s κ. Age- and sex-adjusted ANCOVA compared brain volumes between groups.
Results:Mean whole-brain volume decreased across atrophy grades 0–3 (1122.12, 1068.50, 1034.76, and 968.33 mL; Welch’s F(3, 60.04)=207.30; P<0.001). ROC AUCs for adjacent grades were 0.892, 0.897, and 1.000, with corresponding thresholds of 1099.86, 1056.17, and 995.57 mL. Five-fold cross-validation yielded 78.7% exact agreement (289/367), unweighted κ=0.684, and quadratic-weighted κ=0.856. Adjusted whole-brain volume was 11.98 mL lower in T2DM than in controls (95% CI, −22.67 to −1.30; P=0.028), whereas the overall association between T2DM and atrophy grade was not statistically significant (P=0.059).
Conclusion:Higher report-based atrophy grades were associated with lower whole-brain volumes, with strong quadratic-weighted agreement between volumetric and report-based classifications. Adults with T2DM had lower adjusted brain volumes than controls. Automated volumetry may complement radiologists’ assessments by providing objective quantitative information.
- Full text:202611022213269644432. Хиймэл оюунд суурилсан тархины нийт эзлэхүүний хэмжилт ба радиологичийн тайланд.pdf
