Diagnostic yield and safety of CT-guided transthoracic core needle biopsy for mediastinal lesions (A 10-year single-center cohort study)
- VernacularTitle:Компьютерт томографийн хяналттай голтын үүсгэврийн трансторакаль биопсийн үр дүн ба аюулгүй байдалын судалгаа (Нэг төвт 10 жилийн когорт судалгаа)
- Author:
Tuvshinbayar J
1
;
2
;
Enkhsaruul L
2
;
Gonchigsuren D
3
;
Baasanjav N
1
;
Ichinnorov D
4
;
5
Author Information
1. Ach Medical University, Ulaanbaatar, Mongolia
2. Brilliant General Hospital, Ulaanbaatar, Mongolia
3. Grandmed Hospital, Ulaanbaatar, Mongolia
4. School of Medicine, MNUMS, Ulaanbaatar, Mongolia
5. Mongolia-Japan Hospital, MNUMS, Ulaanbaatar, Mongolia
- Publication Type:Journal Article
- Keywords:
mediastinal lesion;
CT-guided biopsy;
core needle biopsy;
diagnostic yield;
complications;
needle-path depth
- From:
Mongolian Journal of Health Sciences
2026;97(7):76-82
- CountryMongolia
- Language:Mongolian
-
Abstract:
Background:Mediastinal lesions encompass a broad spectrum of malignant and benign conditions, and histopathological confirmation is often required to guide appropriate management. Computed tomography (CT)-guided transthoracic core needle biopsy (CNB) is a less invasive alternative to surgical biopsy; however, data on its diagnostic performance and safety in Mongolia remain limited.
Aim:To evaluate the diagnostic yield and safety of CT-guided transthoracic CNB for mediastinal lesions and to identify factors associated with diagnostic outcomes and procedure-related complications.
Materials and Methods:This retrospective–prospective observational cohort study included 58 CT-guided transthoracic CNB procedures performed in 55 patients with mediastinal lesions. CT characteristics, histopathological diagnoses, procedural variables, and complications were analyzed. Fisher’s exact test, Pearson’s χ² test with Monte Carlo simulation, and the Mann–Whitney U test were applied, with Holm adjustment for multiple comparisons.
Results:The median age was 57 years [IQR, 46–67], and 63.6% of patients were male. Malignancy was confirmed in 76.4%, while 21.8% had non-malignant disease. A specific diagnosis was established in 54 of 58 procedures, yielding a diagnostic yield of 93.1% (95% CI, 83.6–97.3%). CT lesion composition, internal characteristics, and mediastinal location were not significantly associated with diagnostic category (all p>0.05). The overall complication rate was 6.9%, with CIRSE grade ≥3 complications occurring in 1.7%. All complications occurred when the needle-path depth exceeded 7 cm, an association that remained significant after Holm adjustment (adjusted p=0.007).
Conclusion:CT-guided transthoracic core needle biopsy is a highly effective diagnostic procedure with a favorable safety profile for mediastinal lesions. A needle-path depth >7 cm may indicate increased procedural risk and warrants validation in larger studies.
- Full text:202611022148528489913. Компьютерт томографийн хяналттай голтын үүсгэврийн трансторакаль биопсийн үр дүн ба.pdf
