Immunoregulatory effect of fatty acid metabolic reprogramming in hepatocellular carcinoma and targeted therapeutic strategies

VernacularTitle:肝细胞癌脂肪酸代谢重编程的免疫调控效应及靶向治疗策略
Author: Shaohua GUO ¹ ; Chengzheng JIA ² ; Ruiying YU ¹ ; Chenxu LIU ¹ ; Xiang LI ¹ ; Huifan JI ¹ ; Yanhang GAO ¹
Author Information

1. Department of Hepatology， The First Hospital of Jilin University， Changchun 130021， China
2. General Surgery Center， The First Hospital of Jilin University， Changchun 130021， China
Publication Type:Review
Keywords: Carcinoma， Hepatocellular; Fatty Acids; Tumor Microenvironment; Molecular Targeted Therapy
From: Journal of Clinical Hepatology 2026;42(9):2229-2235
CountryChina
Language:Chinese
Abstract: Metabolic reprogramming is a key characteristic of hepatocellular carcinoma， and abnormal fatty acid metabolism is closely associated with tumor immune escape. This article systematically reviews the molecular mechanisms of fatty acid metabolic reprogramming in hepatocellular carcinoma， focusing on key enzymes and their transcriptional regulatory networks within de novo lipogenesis and fatty acid oxidation pathways. This article also analyzes the metabolic heterogeneity between β-catenin-mutant hepatocellular carcinoma and AXIN1-mutant hepatocellular carcinoma and their therapeutic implications， summarizes the multidimensional mechanisms by which the lipid microenvironment regulates immune cell function， and reviews the targeted therapeutic strategies for different molecular subtypes of hepatocellular carcinoma.