Influencing factors for suboptimal response to ursodeoxycholic acid in primary biliary cholangitis and related advances in treatment
- VernacularTitle:原发性胆汁性胆管炎对熊去氧胆酸应答不佳的影响因素及治疗进展
- Author:
Xinyue WU
1
;
Wenjun DU
1
Author Information
- Publication Type:Review
- Keywords: Liver Cirrhosis， Biliary; Ursodeoxycholic Acid; Treatment Outcome; Root Cause Analysis
- From: Journal of Clinical Hepatology 2026;42(9):2217-2223
- CountryChina
- Language:Chinese
- Abstract: Primary biliary cholangitis （PBC） is an autoimmune-mediated chronic cholestatic liver disease. Ursodeoxycholic acid （UDCA） is the first-line treatment drug for PBC， yet some patients with suboptimal biochemical response to UDCA face a significant increase in the risk of disease progression and often have a poor prognosis. This article systematically summarizes the currently established criteria for biochemical response and analyzes the factors and underlying mechanisms associated with suboptimal UDCA response from multiple perspectives including genetic background， demographic factors， immunological features， and the gut-liver axis. Furthermore， it outlines the available second-line treatment drugs and emerging therapies， in order to provide a basis for early identification of high-risk patients and optimization of treatment strategies， as well as a reference for future research directions.
