Impact of the interaction between the gut-liver axis and hepatic iron overload on metabolic dysfunction-associated fatty liver disease and related intervention strategies
- VernacularTitle:肠-肝轴与肝脏铁过载的交互作用对代谢相关脂肪性肝病的影响及相关干预策略
- Author:
Ying LIANG
1
;
Jingjing ZHANG
1
;
Xiaoyan LIU
2
;
Wenxia ZHAO
2
Author Information
- Publication Type:Review
- Keywords: Metabolic Dysfunction-Associated Fatty Liver Disease; Enterohepatic Circulation; Iron Overload; Pathologic Processes
- From: Journal of Clinical Hepatology 2026;42(9):2197-2202
- CountryChina
- Language:Chinese
- Abstract: Metabolic dysfunction-associated fatty liver disease （MAFLD） is a chronic liver condition worldwide mainly caused by overnutrition and insulin resistance （IR）. It encompasses a broad disease spectrum with a high incidence rate and may further progress to hepatitis， liver cirrhosis， and hepatocellular carcinoma. The pathogenesis of MAFLD involves multiple factors， but the specific mechanism of action has not yet been fully elucidated. This article reviews the cutting-edge theory of “gut-liver axis dysfunction-hepatic iron overload”， summarizes the molecular mechanisms by which these two factors regulate intrahepatic lipotoxicity， oxidative stress， IR， and ferroptosis， reveals the pathophysiological process by which they synergistically promote the progression of MAFLD， and elaborates on the therapeutic strategies for MAFLD on this basis， so as to provide a reference for clinical diagnosis and treatment.
