The preventive and therapeutic effects of three ethanol extracts derived from three sources of Stellera chamaejasme L. on imiquimod-induced psoriasis in mice
10.12206/j.issn.2097-2024.202406029
- VernacularTitle:3种狼毒乙醇提取物对咪喹莫特诱导的银屑病小鼠防治作用研究
- Author:
Ying PENG
1
;
Xin LIU
2
;
Yiwen NIE
3
;
Xinhe WANG
2
;
Hua NIAN
4
;
Jianyong ZHU
3
Author Information
1. Department of Pharmacy Research;Department of Pharmacy.
2. , Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China.
3. Department of Pharmacy Research.
4. Department of Pharmacy.
- Publication Type:Originalarticles
- Keywords:
Stellera chamaejasme L.;
Euphorbia fischeriana Steud;
Euphorbia kansuensis Prokh.;
ethanol extract;
psoriasis
- From:
Journal of Pharmaceutical Practice and Service
2026;44(10):502-507
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the preventive and therapeutic effects of ethanol extracts derived from three sources of traditional Chinese medicine: Stellera chamaejasme L., Euphorbia fischeriana Steud. and Euphorbia kansuensis Prokh., on imiquimod （IMQ）-induced psoriasis in mice. Methods Thirty-six male BALB/c mice were randomly divided into the following 6 groups with 6 mice in each group: blank control, model, Stellera chamaejasme, Euphorbia fischeriana, Euphorbia kansuensis, and calcipotriol. Psoriasis area and severity index（PASI） scores were used to record the changes of skin lesions in every group; Hematoxylin-eosin（HE） staining was used to observe the pathological morphology of skin and measure the thickness of the epidermis. Immunohistochemistry was used to detect the expression of nuclear antigen Ki67 in the skin tissues of mice. Results Compared with the model group, the three kinds of ethanol extracts could reduce the PASI score, inhibit epidermal thickening, and decrease expression of Ki67 in the psoriasis mice. Among them, the therapeutic effect of Stellera chamaejasme was the most significant and it was better than the commonly used topical drug calcipotriol. Conclusion The ethanol extract of Stellera chamaejasme had good anti-psoriatic activity, which could inhibit the abnormal proliferation of keratinocytes, reduce the expression of Ki67, and significantly improve psoriasis-like skin lesions.
