Current status and research progress of therapeutic drug monitoring technologies
10.12206/j.issn.2097-2024.202507003
- VernacularTitle:治疗药物监测技术的现状与研究进展
- Author:
Sheng LOU
1
;
Dan LI
2
;
Linfeng ZHANG
1
;
Zeyao LI
1
;
Diya LYU
1
;
Yifeng CHAI
1
Author Information
1. School of Pharmacy, Naval Medical University, Shanghai 200433, China.
2. The Third Affiliated Hospital of Naval Medical University, Shanghai 200438, China.
- Publication Type:Reviews
- Keywords:
therapeutic drug monitoring;
surface plasmon resonance;
bio-layer interferometry;
enzyme-linked immunosorbent assay;
liquid chromatography tandem mass spectrometry
- From:
Journal of Pharmaceutical Practice and Service
2026;44(10):496-501
- CountryChina
- Language:Chinese
-
Abstract:
Therapeutic drug monitoring （TDM） is the core approach for individualized precision medication in clinical practice. Based on pharmacokinetics, it quantitatively measures in vivo drug concentrations using modern analytical techniques, mainly applied to drugs with a narrow therapeutic window, significant adverse reactions, and large interindividual pharmacokinetic variability across multiple categories. TDM plays an irreplaceable role in optimizing therapeutic regimens, reducing drug toxicity, and enhancing rational clinical drug use. TDM-applicable drugs were systematically reviewed in this paper, focusing on the working principles, clinical applications, advantages and limitations of mainstream analytical techniques （immunoassay, liquid chromatography tandem mass spectrometry，LC-MS/MS） and emerging ones （surface plasmon resonance and biolayer interferometry）, which provided a valuable reference for the standardized clinical application of TDM, rational selection of analytical methods, and subsequent technological research and development.
