Progress in the application of 577 nm subthreshold micropulse laser in common fundus diseases
10.3980/j.issn.1672-5123.2026.11.13
- VernacularTitle:577 nm阈值下微脉冲激光治疗常见眼底疾病的应用进展
- Author:
Xiaorong GAO
1
;
Lu CHANG
1
;
Shuai XIONG
1
;
Aijun QIAN
1
;
Yunzhen FEI
1
;
Guangzhen YANG
1
;
Yuqing HE
1
Author Information
1. Kunming Aier Eye Hospital, Kunming 650000, Yunnan Province, China
- Publication Type:Journal Article
- Keywords:
subthreshold micropulse laser;
central serous chorioretinopathy;
branch retinal vein occlusion;
diabetic macular edema;
type 2 macular telangiectasia;
age-related macular degeneration;
subretinal fluid;
Irvine-Gass
- From:
International Eye Science
2026;26(11):1945-1949
- CountryChina
- Language:Chinese
-
Abstract:
The 577 nm subthreshold micropulse laser(577 nm SML)is a non-invasive retinal laser treatment technique that selectively acts on the retinal pigment epithelium(RPE), induces heat shock protein expression, regulates inflammatory response, promotes blood retinal barrier repair, downregulates vascular endothelial growth factor(VEGF)levels, improves Müller cell function, promotes retinal metabolism and functional recovery, and avoids thermal damage caused by traditional threshold lasers. In recent years, 577 nm SML has been widely used in the treatment of various fundus diseases, including central serous chorioretinopathy(CSC), diabetes macular edema(DME), macular edema secondary to retinal vein occlusion(RVO-ME), age-related macular degeneration(ARMD), type 2 macular telangiectasia(MacTel2), persistent subretinal fluid after retinal detachment repair, and Irvine-Gass syndrome. Characterized by favorable safety and repeatability, 577 nm SML possesses high clinical application value and serves as a vital adjuvant and complementary strategy for anti-VEGF therapy. This review aims to summarize the therapeutic mechanisms and clinical applications of 577 nm SML in common fundus diseases, and provide a theoretical basis for its further clinical application.
