Research progress of microcystic macular edema in neuro-ophthalmic diseases
10.3980/j.issn.1672-5123.2026.11.11
- VernacularTitle:微囊样黄斑水肿在神经眼科疾病中的研究进展
- Author:
Xueqing CUI
1
;
Wenjun ZOU
1
Author Information
1. Jiangnan University Medical Center;Wuxi No.2 People's Hospital, Wuxi 214000, Jiangsu Province, China
- Publication Type:Journal Article
- Keywords:
microcystic macular edema;
inner nuclear layer;
neuromyelitis optica spectrum disorder;
optical coherence tomography
- From:
International Eye Science
2026;26(11):1932-1937
- CountryChina
- Language:Chinese
-
Abstract:
Microcystic macular edema(MME)is a characteristic retinal imaging finding characterized by cystic changes within the inner nuclear layer(INL). It was first described in patients with optic neuritis associated with multiple sclerosis(MS). Subsequent studies have shown that MME is also present in a broad spectrum of neuro-ophthalmic disorders, including neuromyelitis optica spectrum disorder(NMOSD), non-arteritic anterior ischemic optic neuropathy(NAION), and hereditary optic neuropathies. Moreover, its presence is closely associated with disease severity and visual dysfunction. Current evidence suggests the occurrence of MME in neuro-ophthalmic diseases may be related to retrograde transsynaptic degeneration and vitreomacular traction.A deeper understanding of the clinical characteristics and pathophysiological mechanisms of MME may provide a new perspective and scientific basis for the clinical diagnosis, disease monitoring and prognosis evaluation of various neuro-ophthalmic diseases.
