Prognostic impact of lymph node dissection modality in patients with ≤2 cm stage ⅠA STAS-positive lung adenocarcinoma
- VernacularTitle:淋巴结清扫方式对≤2 cm ⅠA期气腔播散阳性肺腺癌患者预后的影响
- Author:
Xiao CHEN
1
;
Hangcheng ZHOU
2
;
Mingsheng WU
1
;
Meiqing XU
1
;
Tian LI
1
;
Xiaohui SUN
1
;
Zekai ZHANG
1
;
Yu WANG
1
;
Mingran XIE
1
Author Information
1. Department of Thoracic Surgery, The First Affiliated Hospital of University of Science and Technology of China, Hefei, 230000, P. R. China
2. Department of Pathology, The First Affiliated Hospital of University of Science and Technology of China, Hefei, 230000, P. R. China
- Publication Type:Journal Article
- Keywords:
Lung adenocarcinoma;
spread through air spaces;
lymph node dissection modality;
prognosis
- From:
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery
2026;33(10):1589-1594
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of different lymph node dissection methods on the prognosis of patients with stage ⅠA spread through air spaces (STAS)-positive lung adenocarcinoma measuring ≤2 cm. Methods The clinical data of 3 148 patients with lung adenocarcinoma who underwent surgery at the Department of Thoracic Surgery, The First Affiliated Hospital of University of Science and Technology of China from 2016 to 2018 were retrospectively analyzed. Patients with stage ⅠA STAS-positive lung adenocarcinoma measuring ≤2 cm were included and divided into two groups based on the extent of lymph node dissection: a systematic lymph node dissection (SLND) group and a limited lymph node dissection (LLND) group. Clinicopathological data between the two groups were compared, and a Cox proportional hazards regression model was used for multivariate survival analysis. Results A total of 209 patients (98 males and 111 females) were included. The mean age was (60.42±10.15) years (ranging from 28 to 83 years). All patients successfully completed the surgery. Univariate analysis revealed that the extent of lymph node dissection, past medical history, and micropapillary histological subtype were influencing factors for prognosis. Multivariate analysis indicated that the extent of lymph node dissection, age, and the micropapillary histological subtype were independent influencing factors for prognosis. Furthermore, among STAS-positive patients, those in the SLND group exhibited a better prognosis compared to those in the LLND group. Conclusion The extent of lymph node dissection is an independent prognostic factor for patients with stage ⅠA STAS-positive lung adenocarcinoma measuring ≤2 cm.Performing SLND may be more beneficial for their long-term prognosis.
