Exploring Clinical Application and Mechanism of Huangqi Guizhi Wuwutang Based on Theory of Treating Different Diseases with Same Method
10.13422/j.cnki.syfjx.20260917
- VernacularTitle:基于“异病同治”理论探讨黄芪桂枝五物汤的临床应用及作用机制
- Author:
Jiali ZHANG
1
;
Yubin ZHANG
1
;
Chuang GUO
2
;
Ruoying SONG
2
;
Zhipeng LI
2
;
Yongbing WEN
3
;
Feng LI
3
;
Jiayi GUO
3
Author Information
1. Hunan University of Chinese Medicine， Changsha 410208， China
2. College of Orthopedics and Traumatology， Henan University of Chinese Medicine， Zhengzhou 450046， China
3. Luoyang Orthopedic-Traumatological Hospital of Henan Province （Henan Provincial Orthopedic Hospital）， Luoyang 471002， China
- Publication Type:Journal Article
- Keywords:
treating different diseases with the same method;
Huangqi Guizhi Wuwutang;
blood obstruction syndrome;
clinical application;
mechanism
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2026;32(22):224-235
- CountryChina
- Language:Chinese
-
Abstract:
Huangqi Guizhi Wuwutang was first documented in ZHANG Zhongjing's Synopsis of the Golden Chamber in the Eastern Han Dynasty as the principal formula for treating blood obstruction syndrome. It is composed of Astragali Radix， Cinnamomi Ramulus， Paeoniae Radix Alba， Zingiberis Rhizoma Recens， and Jujubae Fructus. This formula exhibits the effects of replenishing Qi， warming meridians， harmonizing blood， and relieving obstruction， being primarily indicated for blood obstruction syndrome characterized by diminished Yin and Yang functions with external manifestations of bodily numbness. Traditional Chinese medicine （TCM） emphasizes strict adherence to pathogenesis while applying tailored therapies， employing consistent treatment approaches for conditions with diverse clinical presentations but shared pathogenesis， which embodies the principle of treating different diseases with the same method. In modern clinical practice， Huangqi Guizhi Wuwutang is widely applied in multisystem disorders presenting with symptoms such as cutaneous numbness， cold-induced pain and stiffness， and soreness and weakness， including diabetic peripheral neuropathy， cervical radiculopathy， rheumatoid arthritis， coronary heart disease， pediatric spastic cerebral palsy， and recovery phases of cerebral infarction， demonstrating proven efficacy. Modern pharmacological studies confirm its anti-inflammatory， antioxidant-stress， hemorheological-improving， immunomodulatory， and neuroprotective effects by regulating multiple signaling pathways such as nuclear factor （NF）-κB/NOD-like receptor protein 3 （NLRP3） and nuclear factor erythroid 2-related factor 2 （Nrf2）-antioxidant response element （ARE）， thereby addressing common pathological processes including inflammation， hypercoagulability， oxidative stress， immune dysregulation， and neural injury， highlighting the integrated regulatory advantages of TCM formulas with multi-target， multi-level， multi-component， and multi-pathway mechanisms. According to the theory of treating different diseases with the same method and focusing on three core syndromes of blood obstruction， this article systematically reviews and elucidates the clinical extensions and shared mechanisms of this formula， aiming to provide evidence-based insights for the modern adaptation and precise application of this classical formula in orthopedic and related disciplines for chronic musculoskeletal disorders.
