A Cross-Sectional Study on the Distribution of Traditional Chinese Medicine Constitutions and Factors Associated with Hyperuricemia
10.13288/j.11-2166/r.2026.20.011
- VernacularTitle:高尿酸血症患者中医体质分布特点及患病相关因素的横断面研究
- Author:
Zhongyi ZHANG
1
;
Fangli LI
2
;
Shiping HU
2
;
Shujie AN
3
;
Xihuan ZHU
4
;
Jiahui ZHANG
1
;
Luyao JIN
1
;
Yuhan ZONG
5
;
Mengru ZHOU
1
;
Ji WANG
1
;
Huaiyu WANG
1
;
Qi WANG
1
Author Information
1. Wang Qi Academy of Beijing University of Chinese Medicine/National Institute of Traditional Chinese Medicine Constitution and Preventive Medicine，Beijing，100029
2. Shenzhen Hospital （Longgang），Beijing University of Chinese Medicine
3. Xijing Hospital of Air Force Military Medical University
4. Qi-huang Chinese Medicine School，Beijing University of Chinese Medicine
5. The Second School of Clinical Medicine，Guangzhou University of Chinese Medicine
- Publication Type:Journal Article
- Keywords:
hyperuricemia;
traditional Chinese medicine constitution;
single constitution;
mixed constitution
- From:
Journal of Traditional Chinese Medicine
2026;67(20):2210-2218
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo analyze the distribution characteristics of traditional Chinese medicine （TCM） constitution and factors associated with hyperuricemia （HUA） in the HUA population， providing a reference for persona-lized prevention and management of HUA. MethodsA cross-sectional study was conducted among individuals who had completed both serum uric acid （SUA） testing and TCM constitution identification during health examinations. According to SUA levels， participants were divided into a hyperuricemia group and a normal SUA group； according to the constitution identification results， participants were classified into balanced constitution， single biased constitution， and mixed constitution. The distribution characteristics of TCM constitution were compared between the two groups； participants in the hyperuricemia group were stratified by sex and age （≥18 years and ＜40 years， ≥40 years）， and the distribution characteristics of TCM constitution were compared across different sex and age groups. Logistic regression was used to analyze factors associated with HUA， with further stratified analyses by sex and age. ResultsA total of 10 920 participants were included， comprising 4170 cases （38.19%） in the hyperuricemia group and 6750 cases （61.81%） in the normal serum uric acid group. According to TCM constitution， there were 420 cases （3.85%） with balanced constitution， 6108 cases （55.93%） with single biased constitution， and 4392 cases （40.22%） with mixed constitution. In the hyperuricemia group， there were 80 cases （19.05%） with balanced constitution； 2275 cases （37.25%） with single biased constitution， among which damp-heat constitution （1205 cases， 52.97%）， phlegm-dampness constitution （500 cases， 21.98%）， and qi-stagnation constitution （181 cases， 7.96%） accounted for relatively high proportions； and 1815 cases （41.33%） with mixed constitution， among which mixed constitution involving phlegm-dampness （51.35%， 932 cases）， mixed constitution involving blood stasis （47.00%， 853 cases）， and mixed constitution involving damp-heat （41.21%， 748 cases） accounted for relatively high proportions. Logistic regression showed that qi-stagnation constitution （OR=1.68）， mixed constitution involving qi-stagnation （OR=1.53）， mixed constitution involving phlegm-dampness （OR=1.55）， and mixed constitution involving blood stasis （OR=1.50） were independently associated with HUA （P＜0.05）. Sex-stratified analysis showed that mixed constitution involving phlegm-dampness was positively associated with HUA risk in females； age-stratified analysis showed that， among individuals aged ≥18 and ＜40 years， qi-stagnation constitution， mixed constitution involving qi stagnation， and mixed constitution involving phlegm-dampness were positively associated with HUA risk （all P＜0.05）. ConclusionThe prevalence of HUA differs markedly by sex and age. Mixed constitution accounts for a higher proportion of HUA patients. Qi-stagnation constitution， mixed constitution involving qi stagnation， mixed constitution involving phlegm-dampness， and mixed constitution involving blood stasis are associated with HUA. Notably， the specific association of mixed constitution involving phlegm-dampness in females and qi-stagnation constitution in young adults is particularly prominent.
