Application and Reflection of Simiao Yong'an Tang in Pan-vascular Diseases
10.13422/j.cnki.syfjx.20260896
- VernacularTitle:四妙勇安汤在泛血管疾病中应用与思考
- Author:
Aolin LI
1
;
Kangzheng GUO
2
;
Xitong SUN
2
;
Lerong YU
2
;
Wei ZHOU
2
;
Junping ZHANG
1
Author Information
1. First Teaching Hospital of Tianjin University of Traditional Chinese Medicine（TCM），Tianjin/National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion，Tianjin 300383，China
2. Graduate School of Tianjin University of TCM，Tianjin 300193，China
- Publication Type:Journal Article
- Keywords:
pan-vascular diseases;
Simiao Yong'an Tang;
inflammation;
traditional Chinese medicine;
compound formula;
research progress
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2026;32(21):235-243
- CountryChina
- Language:Chinese
-
Abstract:
Pan-vascular diseases are a group of diseases involving the systemic vascular system， with vascular lesions （especially atherosclerosis） as a common pathological feature. Pan-vascular diseases have attracted widespread attention due to the high healthcare burden that accompanies high morbidity. Inflammation is the core pathogenesis of pan-vascular diseases. Targeted anti-inflammatory strategies have achieved certain success in basic research. However， due to the increased risk of infection， their clinical application has been hindered. Simiao Yong'an Tang （SMYAT）， which has the effects of nourishing Yin， detoxifying， and activating blood， demonstrates unique therapeutic advantages. Clinical evidence indicates that SMYAT alone or in combination with conventional Western Medicine/other compound formulas/non-drug therapies can effectively alleviate the clinical symptoms and traditional Chinese medicine （TCM） syndromes of pan-vascular diseases. At the same time， it can reduce the serum levels of inflammatory factors and the risk of infection， improve glucose and lipid metabolism and blood viscosity， and promote wound healing， thereby enhancing the quality of life. The research on the pharmacological material basis indicates that when SMYAT enters the bloodstream， it can be converted into various active components such as harpagide， harpagoside， and chlorogenic acid. Basic research suggests that SMYAT can exert anti-inflammatory effects through multiple pathways and targets， such as interfering with immune cell adhesion and aggregation， macrophage polarization， foam cell autophagy， neovascularization in the outer membrane and plaque， lipid metabolism and cholesterol reverse transport. The current research lacks comprehensive discussion on vascular diseases. In-depth studies on the effects and mechanisms of SMYAT can provide new therapeutic approaches for pan-vascular diseases. Moreover， they help to gain an overall understanding of the disease progression， demonstrating the superiority of the TCM concept of treating different diseases with the same method. This paper provides a systematic overview of the TCM and Western Medicine understanding of pan-vascular diseases， the theoretical framework and material basis of SMYAT， and the progress of clinical and basic research on SMYAT treatment of pan-vascular diseases. The ultimate goal is to provide theoretical evidence and guidance for the development and application of SMYAT in the field of pan-vascular diseases. In the future， further research should be conducted to standardize the compound formula and explore the mechanism of treatment with integrated TCM and Western Medicine.
