Multimodal Echocardiography for Subclinical Myocardial Mechanical Dysfunction in Brugada Syndrome
10.11714/jsysu.med.YX20260056
- VernacularTitle:多模态超声心动图分析Brugada综合征隐匿性心肌机械功能异常
- Author:
Hanlu LÜ
1
;
Yingmei LIU
1
Author Information
1. Department of Cardiology，Sun Yat-sen Memorial Hospital，Sun Yat-sen University，Guangzhou 510120，China
- Publication Type:Journal Article
- Keywords:
Brugada syndrome;
speckle tracking echocardiography;
myocardial strain;
mechanical dispersion;
myocardial performance index
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2026;47(4):709-714
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveThis study aimed to evaluate the myocardial mechanical characteristics in patients with Brugada syndrome （BrS） using multimodal echocardiography， to provide imaging evidence for the assessment of occult myocardial mechanical abnormalities in BrS. MethodsPatients diagnosed with BrS in Sun Yat-sen Memorial Hospital between January 2020 and December 2023 were enrolled. Speckle-tracking echocardiography （STE） was performed to measure left ventricular global longitudinal strain （LV-GLS）， right ventricular free wall longitudinal strain （RVFW-LS）， and right ventricular global longitudinal strain （RV-GLS）， as well as corresponding mechanical dispersion parameters （LV-MD， RVFW-MD， RV-MD）. Left and right ventricular myocardial performance indices （LV-MPI， RV-MPI） were calculated using tissue Doppler imaging （TDI）. ResultsAll five BrS patients had normal conventional ventricular systolic function， while marked individual differences were observed in multimodal echocardiographic parameters. Patients with high-risk phenotype， characterized by both spontaneous type 1 Brugada electrocardiogram and SCN5A gene mutation， exhibited elevated myocardial performance indexes （maximum LV-MPI 0.53， maximum RV-MPI 0.67） or increased mechanical dispersion （maximum LV-MD 61 ms）. ConclusionPatients with BrS present subclinical myocardial mechanical dysfunction undetectable by conventional echocardiography. Combined assessment of myocardial performance index and multi-parameter STE can identify subtle impairments in ventricular function and systolic synchronicity. Multimodal echocardiography has valuable potential for the assessment of subclinical myocardial injuries in BrS.
