The Predictive Value of Serum Cystatin C and Trabecular Bone Score for Postoperative Fracture Recurrence in Elderly Patients with Osteoporotic Vertebral Fractures
10.11714/jsysu.med.YX20250162
- VernacularTitle:CysC与骨小梁评分对老年骨质疏松性椎体骨折术后骨折再发的预测价值
- Author:
Ruiqiang RAO
1
;
Song SHANG
1
;
Minggui WANG
1
Author Information
1. Department of Orthopedics， Fuling Hospital Affiliated to Chongqing University， Chongqing 408000， China
- Publication Type:Journal Article
- Keywords:
osteoporotic fracture;
cystatin C;
trabecular bone score;
fracture recurrence;
prediction
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2026;47(2):354-359
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo explore the predictive value of serum cystatin C （CysC） and trabecular bone score （TBS） for postoperative fracture recurrence in elderly patients with osteoporotic vertebral fractures. MethodsA total of 100 elderly patients with osteoporotic vertebral fractures who were treated surgically at Fuling Hospital Affiliated to Chongqing University from June 2022 to June 2023 were followed up for 2 years. They were divided into the poor group （31 cases） and the good group （69 cases） based on the postoperative fracture recurrence. Pearson analysis was used to analyze the correlation between serum CysC and TBS， Cox analysis was used to analyze the influencing factors of postoperative fracture recurrence in elderly patients with osteoporotic vertebral fractures， and ROC analysis was used to analyze the predictive value of serum CysC and TBS for postoperative fracture recurrence in patients. ResultsThe proportion of bone cement penetration and serum CysC in the poor group were significantly higher than those in the good group （χ2 = 4.977， P = 0.026； t = 4.749， P = 0.000）， while the proportion of postoperative anti-osteoporosis treatment， bone mineral density T value， and TBS were significantly lower than those in the good group （χ2 = 4.229， P = 0.040； t = 2.065， P = 0.042； t = 5.163， P = 0.000）. Serum CysC was negatively correlated with TBS （r = -0.318， P = 0.001）. Elevated serum CysC was a risk factor for postoperative fracture recurrence in elderly patients with osteoporotic vertebral fractures （P < 0.05）， while elevated TBS was a protective factor （P < 0.05）. The AUC of serum CysC for predicting postoperative fracture recurrence in patients was 0.786 （95%CI = 0.679-0.894）， with a sensitivity of 77.42% and a specificity of 71.01%. The AUC of TBS for predicting postoperative fracture recurrence in patients was 0.795 （95%CI = 0.698-0.892）， with a sensitivity of 74.19% and a specificity of 79.71%. The AUC of the combination of serum CysC and TBS for predicting postoperative fracture recurrence in patients was 0.858 （95%CI = 0.773-0.943）， with a sensitivity of 74.19% and a specificity of 82.61%. The combination of the two had a higher predictive value for postoperative fracture recurrence in patients. ConclusionsElderly patients with osteoporotic vertebral fractures who experience postoperative fracture recurrence have elevated serum CysC and decreased TBS. The combination of serum CysC and TBS has a certain predictive value for postoperative fracture recurrence in elderly patients with osteoporotic vertebral fractures.
