Regulation of Pyroptosis via the NLRP3-GSDMD Pathway and Its Immunotherapeutic Strategy in Ischemic Stroke
10.11714/jsysu.med.YX20250151
- VernacularTitle:基于NLRP3-GSDMD通路的细胞焦亡调控与缺血性脑卒中的免疫治疗策略
- Author:
Chenlei WAN
1
;
Binbin REN
1
Author Information
1. Henan University of Traditional Chinese Medicine， School of Rehabilitation Medicine， Zhengzhou 450046， China
- Publication Type:Review
- Keywords:
NLRP3-GSDMD pathway;
pyroptosis;
ischemic stroke;
immune inflammation;
treatment
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2026;47(2):216-226
- CountryChina
- Language:Chinese
-
Abstract:
Ischemic stroke （IS） is a neurological disorder with high rates of disability and mortality worldwide， characterized by complex interactions between immune-inflammatory responses and various forms of cell death during its onset and progression. In recent years， pyroptosis， a form of programmed cell death mediated by inflammasomes， has attracted increasing attention for its critical role in post-stroke neuronal injury. Among the underlying mechanisms， the NOD-like receptor family pyrin domain-containing 3 inflammasome-Gasdermin D （NLRP3-GSDMD） pathway， as the central signaling axis of pyroptosis， plays a crucial regulatory role in immune responses and neuronal dysfunction following cerebral ischemia. However， current therapeutic strategies targeting this pathway remain limited by insufficient specificity and an incomplete understanding of its mechanisms of action. Therefore， this review summarizes the immuno-inflammatory pathology of IS， the mechanisms of the NLRP3-GSDMD pathway and pyroptosis， as well as emerging immunotherapeutic strategies targeting this signaling axis， aiming to provide insights and references for future research on pyroptosis-based immunomodulatory therapies for stroke.
