Advances of the Mechanisms Underlying Traditional Chinese Medicine Targeting the PI3K/Akt Pathway against Parkinson's Disease
10.11714/jsysu.med.YX20250175
- VernacularTitle:中药调控PI3K/Akt信号通路治疗帕金森病的机制研究进展
- Author:
Yanfei QU
1
;
Yanjie LI
2
Author Information
1. School of Rehabilitation Medicine， Henan University of Chinese Medicine， Zhengzhou 450046， China
2. Department of Rehabilitation， Henan Province Hospital of Traditional Chinese Medicine //Department of Rehabilitation， The Second Affiliated Hospital of Henan University of Chinese Medicine， Zhengzhou 450002， China
- Publication Type:Review
- Keywords:
Parkinson's disease;
traditional chinese medicine;
PI3K/Akt;
signaling pathway;
mechanisms
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2026;47(2):203-215
- CountryChina
- Language:Chinese
-
Abstract:
Parkinson’s disease （PD） is a neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta （SNpc） of the midbrain. Current therapeutic strategies are unable to reverse the neurodegenerative process， highlighting an urgent need for neuroprotective interventions. The phosphatidylinositol 3-kinase/protein kinase B （PI3K/Akt） signaling pathway， as a key pathway regulating cell survival， has emerged as an important target for PD intervention. In recent years， traditional Chinese medicine （TCM）， with its distinctive properties of multi-targeted action and holistic regulation， has demonstrated considerable potential in PD neuroprotection research based on the PI3K/Akt pathway. However， most studies in this field are currently limited to the preclinical stage， and there is a lack of high-quality clinical evidence that correlates patients’ clinical endpoints ［e.g.， Unified Parkinson’s Disease Rating Scale （UPDRS） scores］ with pathway-related biomarkers ［e.g.， phosphorylated Akt （p-Akt） levels］， which hinders its clinical translation. Therefore， this paper reviews the research progress of TCM in the prevention and treatment of PD by regulating the PI3K/Akt pathway， and prospects the future direction of integrated research on “clinical phenotype-pathway activity-TCM intervention”， aiming to provide references for relevant basic research and clinical translation.
