Progress in Research on Regulatory Cell Death in Spinal Cord Injury
10.11714/jsysu.med.YX20250126
- VernacularTitle:调节性细胞死亡在脊髓损伤中作用的研究进展
- Author:
Yiting ZHAO
1
;
Hewei QIN
1
Author Information
1. Rehabilitation Medicine College， Henan University of Chinese Medicine， Zhengzhou 450046， China
- Publication Type:Review
- Keywords:
spinal cord injury （SCI）;
regulated cell death （RCD）;
apoptosis;
autophagy;
pyroptosis;
ferroptosis;
cuproptosis;
research progress
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2026;47(1):106-118
- CountryChina
- Language:Chinese
-
Abstract:
Spinal cord injury （SCI）， a prevalent neurological disorder， is primarily caused by mechanical trauma， leading to extensive impairments in sensory， motor， and autonomic functions， significantly compromising patients' quality of life. Accumulating evidence indicates that various forms of regulated cell death （RCD）， including apoptosis， necroptosis， autophagy， pyroptosis， ferroptosis， and copper-dependent cell death， play critical roles in the pathogenesis and progression of SCI， with notable interplay among these pathways. This review aims to summarize the current understanding of RCD-related mechanisms in SCI and highlight recent advances in therapeutic strategies targeting cell death inhibitors， stem cell transplantation， and tissue engineering approaches， thereby providing insights for future basic research and clinical interventions.
