The Mechanism and Potential Therapeutic Targets of SUMOylation in Ischemic Stroke
10.11714/jsysu.med.YX20250147
- VernacularTitle:类泛素化修饰在缺血性脑卒中的机制及潜在治疗靶点
- Author:
Nannan LIU
1
;
Xiaodong FENG
2
Author Information
1. School of Rehabilitation Medicine， Henan University of Traditional Chinese Medicine， Zhengzhou 450046，China
2. Rehabilitation Center ， The First Affiliated Hospital， Henan University of Traditional Chinese Medicine，Zhengzhou 450000，China
- Publication Type:Review
- Keywords:
ischemic stroke;
SUMOylation;
pathological mechanism;
therapeutic target;
review
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2026;47(1):84-94
- CountryChina
- Language:Chinese
-
Abstract:
Ischemic stroke （IS） is the second leading cause of death worldwide， characterized by high morbidity and disability rates. Small ubiquitin-related modifier （SUMO） modification， a crucial post-translational modification， plays a vital role in the pathogenesis of IS. This review elucidates the relationship between SUMOylation and IS by detailing how SUMOylation regulates key pathological processes， including neuroinflammation， mitochondrial dynamics， apoptosis， oxidative stress， and angiogenesis. Furthermore， it summarizes potential therapeutic targets of SUMOylation for IS treatment， aiming to provide new directions for clinical management.
