Human Induced Pluripotent Stem Cells in Cardiovascular Disease： Mechanisms and Translational Applications
10.11714/jsysu.med.YX20250135
- VernacularTitle:hiPSC在心血管疾病机制和转化应用中的研究进展
- Author:
Liang HUANG
1
;
Qiuling XIANG
1
Author Information
1. Zhongshan School of Medicine，Sun Yat-sen University，Guangzhou 510080，China
- Publication Type:Review
- Keywords:
human induced pluripotent stem cell;
cardiovascular diseases;
cardiomyocytes;
non-myocytes;
cardiac organoids
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2026;47(1):43-54
- CountryChina
- Language:Chinese
-
Abstract:
Cardiovascular diseases are the leading cause of mortality worldwide， yet their pathogenic mechanisms and functional repair remain incompletely understood. The emergence and development of human induced pluripotent stem cells （hiPSC） have provided unprecedented opportunities for cardiovascular disease research， and markedly enhanced our understanding of cardiovascular disease mechanisms. This review summarizes recent advances in cardiovascular cells and cardiac organoids derived from hiPSC， and presents our team's related research findings in this field. It highlights the induction and differentiation of hiPSC-derived cardiomyocytes and non-myocytes， as well as their roles in disease modeling， functional repair， drug screening， and mechanistic investigation. Furthermore， the current applications of hiPSC-derived cardiac organoids in cardiovascular disease research are also discussed.
