Research Progress on the Pathogenic Mechanisms and Prevention of Angiostrongylus cantonensis Infection
10.11714/jsysu.med.YX20250163
- VernacularTitle:广州管圆线虫感染致病机制及研究进展
- Author:
Xi SUN
1
;
Zhongdao WU
1
Author Information
1. Department of Parasitology， Zhongshan School of Medicine//Key Laboratory of Tropical Disease Prevention and Control of the Ministry of Education， Sun Yat-sen University， Guangzhou 510080， China
- Publication Type:Journal Article
- Keywords:
Angiostrongylus cantonensis;
eosinophilia meningitis;
pathogenesis;
immunomodulation;
multi-omics
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2026;47(1):1-10
- CountryChina
- Language:Chinese
-
Abstract:
Angiostrongyliasis cantonensis is a major food-borne zoonotic parasitic disease caused by Angiostrongylus cantonensis（AC）， representing a significant threat to human health. Upon infection， AC larvae penetrate the intestinal wall and migrate through the liver and lungs to the central nervous system （CNS）. This process leads to various pathological conditions characterized by pronounced eosinophilia， most notably eosinophilic meningitis， encephalitis， ocular complications， and pneumonia. Elucidating the mechanisms of AC-induced tissue damage and its molecular pathogenesis is essential for the prevention and effective treatment of angiostrongyliasis. This review systematically synthesizes recent advances from multi-omics， pathology， and immunology to explore the mechanisms of infection， multi-organ pathogenesis， and host immune regulation. The goal is to provide a theoretical framework for enhancing diagnostic precision， optimizing clinical treatments， and strengthening epidemiological control of this disease.
