Fitting Degrees of Animal Models of Colorectal Cancer Liver Metastasis with Clinical Characteristics of Disease in Western Medicine and Syndromes in Traditional Chinese Medicine
10.13422/j.cnki.syfjx.20251311
- VernacularTitle:基于中西医病证特点的结直肠癌肝转移动物模型的临床吻合度分析
- Author:
Fengru JIANG
1
;
Feng HE
1
;
Minghan HUANG
2
;
Youcheng HE
1
Author Information
1. Shanghai University of Traditional Chinese Medicine（TCM）， Shanghai 201203，China
2. The Second People's Hospital Affiliated to Fujian University of TCM， Fuzhou 350003，China
- Publication Type:Journal Article
- Keywords:
colorectal cancer liver metastasis;
animal model;
fitting degree with clinical characteristics;
characteristics of disease in Western medicine and syndromes in traditional Chinese medicine
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2026;32(21):262-272
- CountryChina
- Language:Chinese
-
Abstract:
The liver is the most common target organ for hematogenous metastasis in colorectal cancer （CRC）. Colorectal cancer liver metastasis （CRLM） represents one of the major challenges in CRC treatment and is a leading cause of mortality in CRC patients. The establishment of clinically relevant animal models is crucial for investigating disease pathogenesis and developing therapeutic interventions. This study systematically reviews the existing animal models of CRLM to evaluate the fitting degrees of these models with clinical characteristics of disease in Western medicine and syndromes in traditional Chinese medicine （TCM）， with reference to current diagnostic criteria. The findings indicate that the models of orthotopic spontaneous liver metastasis exhibit high fitting degrees with clinical characteristics of disease in Western medicine， yet they are limited by long modeling timelines and inconsistent success rates. In contrast， the models of ectopic experimental liver metastasis demonstrate low fitting degrees with clinical characteristics of disease in Western medicine but offer technical maturity， model stability， and higher success rates. Genetically modified models show high fitting degrees with clinical characteristics of disease in Western medicine， though their liver metastasis success rates remain unclear. Currently， TCM syndrome models of CRLM include liver-spleen disharmony， Qi-blood deficiency， spleen-kidney Yang deficiency， and internal stagnation of blood stasis-toxin. TCM researchers should intensify the research and development of TCM syndrome models of CRLM， with an emphasis on refining behavioral descriptions of existing models. Future efforts should focus on establishing accurate， standardized， and comprehensively evaluated CRLM models， along with improving assessment criteria. This will provide more reliable tools for elucidating the disease mechanisms and advancing therapeutic research in both Western medicine and TCM frameworks.
