Endoplasmic reticulum stress and pulmonary arterial hypertension： from pathological mechanisms to new perspectives on targeted intervention
10.19405/j.cnki.issn1000-1492.2026.08.023
- VernacularTitle:内质网应激与肺动脉高压：从病理机制到靶向干预的新视角
- Author:
Yuxi CAO
1
;
Zhifeng XUE
1
;
Siyi ZHOU
2
;
Xiansheng LIU
1
Author Information
1. Department of Respiratory and Critical Care Medicine， The Third Hospital of Shanxi Medical University （Shanxi Bethune Hospital， Shanxi Academy of Medical Sciences， Tongji Shanxi Hospital）， Taiyuan 030032
2. Tongji Hospital， Tongji Medical College， Huazhong University of Science and Technology， Key Laboratory of Respiratory Diseases， National Health Commission of the People's Republic of China， Wuhan 430030
- Publication Type:Journal Article
- Keywords:
pulmonary hypertension;
pulmonary vascular remodeling;
endoplasmic reticulum;
phenotypic transformation;
endoplasmic reticulum stress;
unfolded protein response;
targeted therapy
- From:
Acta Universitatis Medicinalis Anhui
2026;61(8):1498-1504
- CountryChina
- Language:Chinese
-
Abstract:
Pulmonary hypertension （PH） is a life-threatening condition characterized by a progressive elevation in pulmonary vascular pressure， ultimately leading to right ventricular dysfunction and failure. The core pathological features of PH include abnormal contraction of small pulmonary arteries and vascular remodeling. In recent years， endoplasmic reticulum stress （ERS）， a critical adaptive response of cells to internal and external stressors， has been shown to play a key role in the development and progression of PH. Through the activation of major signaling pathways such as protein kinase R-like endoplasmic reticulum kinase （PERK）， inositol-requiring enzyme 1α （IRE1α）， and activating transcription factor 6 （ATF6）， ERS is directly involved in regulating aberrant cellular behaviors and vascular remodeling in PH. This review systematically discusses the specific role of ERS in the pathogenesis of PH and evaluates its potential as a therapeutic target， aiming to provide a theoretical foundation for novel clinical interventions in PH.
