Helicobacter pylori infection and neuropsychiatric disorders： a review of research progress
10.19405/j.cnki.issn1000-1492.2026.08.022
- VernacularTitle:幽门螺杆菌感染与神经精神疾病关联的研究进展
- Author:
Xingxu YI
1
;
Rong SONG
2
;
Chuan LI
2
;
Yanhong FANG
2
;
Xin YU
2
;
Zhiyuan TANG
2
;
Hong SU
2
Author Information
1. The Third People′s Hospital of Hefei， Hefei Third Clinical College of Anhui Medical University， Hefei Prevention and Treatment Center for Occupational Diseases， Hefei 230041
2. Department of Epidemiology and Health Statistics， School of Public Health， Anhui Medical University， Hefei 230032
- Publication Type:Journal Article
- Keywords:
Helicobacter pylori;
gut-brain axis;
mental illness;
nervous system;
neuroinflammation;
microbiota;
gastrointestinal homeostasis
- From:
Acta Universitatis Medicinalis Anhui
2026;61(8):1492-1497
- CountryChina
- Language:Chinese
-
Abstract:
Helicobacter pylori （H. pylori） infection is not only associated with gastrointestinal diseases， but also potentially links with neuropsychiatric disorders revealed by recent studies. Through a systematic review of the existing literature， this review summarizes epidemiological evidence for the association between H. pylori infection and diseases such as Parkinson′s disease （PD）， Alzheimer′s disease （AD）， multiple sclerosis （MS）， migraine， depression， and anxiety disorders， and further explores potential mechanisms by which it affects central nervous system function， including neural pathways mediated by the enteric nervous system and the vagus nerve， immune pathways mediated by inflammatory cytokines， and endocrine pathways mediated by gut microbial metabolites. Additionally， the current challenges facing H. pylori eradication therapy and the prospects for emerging adjuvant strategies such as probiotics and fecal microbiota transplantation are discussed. Finally， future research directions are outlined， emphasizing the need for prospective cohort studies based on standardized diagnostic methods and further investigation using animal models to elucidate the pathophysiological mechanisms， with the aim of providing new perspectives for the prevention， treatment， and early intervention of related neuropsychiatric disorders.
