Stem cell therapy for retinal degeneration： advances and challenges

VernacularTitle:干细胞治疗视网膜变性疾病的研究进展和挑战
Author: Xinyue LUO ¹ ; Licun MO ¹ ; Leping CHENG ¹
Author Information

1. Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application Co-constructed by the Province and Ministry， Guangxi Medical University， Guangxi Key Laboratory of Regenerative Medicine， Nanning 530021
Publication Type:Review
Keywords: stem cells; retinal degenerative diseases; age-related macular degeneration; retinitis pigmentosa; Stargardt disease; CRISPR gene-editing technology
From: Acta Universitatis Medicinalis Anhui 2026;61(8):1486-1491
CountryChina
Language:Chinese
Abstract: Retinal degeneration （RD） encompasses a group of disorders marked by progressive apoptosis of retinal cells and loss of retinal structural integrity， ultimately resulting in blindness. In recent years， the number of individuals affected by RD-related vision loss has been steadily increasing， seriously compromising both the physical and mental health of patients and imposing a considerable economic burden on society. Conventional therapies currently available are largely unable to repair or regenerate the damaged retina. This review summarizes the recent advances and challenges in stem cell therapy for retinal degenerative diseases.