Change and significance of IL-18 and Th1 in cytomegalovirus infection after pediatric liver transplantation
10.19405/j.cnki.issn1000-1492.2026.08.016
- VernacularTitle:儿童肝移植术后巨细胞病毒感染患儿外周血IL-18和Th1的变化及意义
- Author:
Yiwen GAO
1
;
Chun LIU
2
;
Dan LI
3
;
Jiawei MU
1
;
Yuliang WANG
1
Author Information
1. Tianjin Institute of Urology， The Second Hospital of Tianjin Medical University， Tianjin 300211
2. Blood Transfusion Department， Tianjin First Central Hospital， Tianjin 300192
3. Department of Clinical Laboratory Medicine， Fushun Central Hospital， Fushun 113006
- Publication Type:Journal Article
- Keywords:
pediatric liver transplantation;
cytomegalovirus;
interleukin-18;
interleukin-10;
interferon-γ;
T helper lymphocytes
- From:
Acta Universitatis Medicinalis Anhui
2026;61(8):1453-1457
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the change of interleukin （IL）-18 and Th1， Th2 of CD3+CD8- T helper lymphocytes in pediatric liver transplantation with cytomegalovirus （CMV） infection. MethodsA total of 40 pediatric patients who underwent pediatric liver transplantation were collected. Patients were divided into the CMV group （n=20） and the non-infected group （n=20） according to whether CMV infection occurred. The plasma IL-18 levels were determined by enzyme-linked immunosorbent assay （ELISA）. The expression percentage of IFN-γ and IL-10 of CD3+CD8- T lymphocytes （Th1 and Th2） in peripheral blood were determined with flow cytometry. ResultsThe expression level of plasma IL-18 significantly increased in the CMV group compared with that in non-infected group （P<0.01）. The expression percentage of Th1 in peripheral blood significantly decreased in the CMV group compared with that in non-infected group （P<0.01）. No significant difference was found in the expression percentage of Th2 between CMV group and non-infected group. IL-18 levels were negatively correlated with the Th1 （P<0.05）. ConclusionThe elevated IL-18 levels along with polarized Th 1 subsets’ imbalance involves in the pathogenesis of CMV infection in pediatric liver transplantation.
