Research progress on the mechanism of traditional Chinese medicine regulating regulated cell death to ameliorate sarcopenia：a review
- VernacularTitle:中药调控调节性细胞死亡改善肌少症的机制研究进展
- Author:
Ting DAI
1
;
Jinyu HUANG
2
;
Xiaodong FENG
3
;
Zhihai FENG
4
Author Information
1. Dept. of Rehabilitation，Henan Provincial Hospital of Traditional Chinese Medicine （The Second Affiliated Hospital of Henan University of Chinese Medicine），Zhengzhou 450002，China
2. Heart Center/National Regional （Traditional Chinese Medicine） Cardiovascular Diagnosis and Treatment Center，The First Affiliated Hospital of Henan University of Chinese Medicine，Zhengzhou 450003，China
3. Dept. of Rehabilitation，The First Affiliated Hospital of Henan University of Chinese Medicine，Zhengzhou 450003，China
4. Dept. of Endocrinology，The First Affiliated Hospital of Henan University of Chinese Medicine，Zhengzhou 450003，China
- Publication Type:Journal Article
- Keywords:
traditional Chinese medicine;
sarcopenia;
regulated cell death;
Molecular mechanisms
- From:
China Pharmacy
2026;37(18):2478-2484
- CountryChina
- Language:Chinese
-
Abstract:
Regulated cell death （RCD） is a genetically determined， active and programmed form of cell death， mainly including apoptosis， autophagy， ferroptosis， pyroptosis， PANoptosis and other patterns. Dysregulation of RCD plays a pivotal role in the occurrence and progression of sarcopenia. Due to the advantages of abundant targets， diverse mechanisms of action and high safety profile， traditional Chinese medicine （TCM） has attracted considerable attention in regulating RCD， and preventing and treating sarcopenia. Through a review of the mechanisms of RCD in sarcopenia， and recent research progress on how TCM modulates RCD to improve sarcopenia， this paper reveals that single TCM herbs and their extracts （e.g.， Puerariae Lobatae Radix， and extracts of Schisandrae Chinensis Fructus， Myristicae Semen and Cistanches Herba）， active components and effective fractions of TCM （e.g.， resveratrol， polydatin， curcumin）， as well as TCM compound formulas （e.g.， Buzhong yiqi decoction， Erjing pills， Huangqi guizhi wuwu decoction， Shuanghe decoction）， can modulate RCD through multiple pathways， including the inhibition of apoptosis， pyroptosis， ferroptosis and PANoptosis， and the modulation of autophagy， thereby alleviating sarcopenia.
